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SMILES: Cc1cc(Nc2ccc3nc([nH]c3c2)C(F)(F)F)n2ncnc2n1

InChI Key: InChIKey=WACHELJUZZIQEU-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50345386   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Plasmodium falciparum)		BDBM50345386
PNG
(5-Methyl-N-(2-(trifluoromethyl)-1H-benzo[d]imidazo...)
Show SMILES Cc1cc(Nc2ccc3nc([nH]c3c2)C(F)(F)F)n2ncnc2n1
Show InChI InChI=1S/C14H10F3N7/c1-7-4-11(24-13(20-7)18-6-19-24)21-8-2-3-9-10(5-8)23-12(22-9)14(15,16)17/h2-6,21H,1H3,(H,22,23)
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UniChem

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Article
PubMed
n/an/a 2.10E+4n/an/an/an/an/an/a



University of Washington

Curated by ChEMBL


Assay Description
Inhibition of His6-tagged recombinant Plasmodium falciparum dihydroorotate dehydrogenase expressed in Escherichia coli using L-dihydroorotate as subs...

J Med Chem 54: 3935-49 (2011)


Article DOI: 10.1021/jm200265b
BindingDB Entry DOI: 10.7270/Q2FN16HS
More data for this
Ligand-Target Pair