BDBM50345558 3-(2-(2-methylthiazol-4-yl)ethynyl)-1,5-dibromobenzene::CHEMBL1784604

SMILES: Cc1nc(cs1)C#Cc1cc(Br)cc(Br)c1

InChI Key: InChIKey=FWXCHAMXBMLXBD-UHFFFAOYSA-N

Data: 1 KI  1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50345558   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor (Rattus norvegicus (Rat))	BDBM50345558 (3-(2-(2-methylthiazol-4-yl)ethynyl)-1,5-dibromoben...) Show SMILES Cc1nc(cs1)C#Cc1cc(Br)cc(Br)c1 Show InChI InChI=1S/C12H7Br2NS/c1-8-15-12(7-16-8)3-2-9-4-10(13)6-11(14)5-9/h4-7H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.690	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Institute for Neurodegenerative Disorders Curated by ChEMBL					Assay Description Displacement of [3H]methoxy-PEPY from rat mGluR5 expressed in human HEK-293 cells by liquid scintillation counting				Bioorg Med Chem Lett 21: 3243-7 (2011) Article DOI: 10.1016/j.bmcl.2011.04.047 BindingDB Entry DOI: 10.7270/Q290244M
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor (Rattus norvegicus (Rat))	BDBM50345558 (3-(2-(2-methylthiazol-4-yl)ethynyl)-1,5-dibromoben...) Show SMILES Cc1nc(cs1)C#Cc1cc(Br)cc(Br)c1 Show InChI InChI=1S/C12H7Br2NS/c1-8-15-12(7-16-8)3-2-9-4-10(13)6-11(14)5-9/h4-7H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.45	n/a	n/a	n/a	n/a	n/a	n/a
Institute for Neurodegenerative Disorders Curated by ChEMBL					Assay Description Antagonist activity at rat mGluR5 expressed in human HEK-293 cells assessed as inhibition of glutamate-induced intracellular calcium mobilization				Bioorg Med Chem Lett 21: 3243-7 (2011) Article DOI: 10.1016/j.bmcl.2011.04.047 BindingDB Entry DOI: 10.7270/Q290244M
					More data for this Ligand-Target Pair