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SMILES: Cc1ccc(F)cc1C(O)(CC1C[C@H]2CC[C@H](C1)[N+]2(C)C)c1cc(F)ccc1C

InChI Key: InChIKey=LBKRXXLTIFHWRI-FGZHOGPDSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50345686   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))		BDBM50345686
PNG
((3-endo)-1,1-Bis(5-fluoro-2-methylphenyl)-2-(8,8-d...)
Show SMILES Cc1ccc(F)cc1C(O)(CC1C[C@H]2CC[C@H](C1)[N+]2(C)C)c1cc(F)ccc1C |r,TLB:10:11:18:14.15|
Show InChI InChI=1S/C25H32F2NO/c1-16-5-7-19(26)13-23(16)25(29,24-14-20(27)8-6-17(24)2)15-18-11-21-9-10-22(12-18)28(21,3)4/h5-8,13-14,18,21-22,29H,9-12,15H2,1-4H3/q+1/t21-,22-/m1/s1
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Similars
Article
PubMed
n/an/a 37n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against human M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR

J Med Chem 52: 5241-52 (2010)


Article DOI: 10.1021/jm900736e
BindingDB Entry DOI: 10.7270/Q2PK0H54
More data for this
Ligand-Target Pair