BDBM50348512 CHEMBL1801309

SMILES: Fc1cccc(c1)-c1cc2-c3oc4c(c3CCc2cn1)C(=O)NCC41CNC1

InChI Key: InChIKey=WNLOCCXVPMELDQ-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50348512   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
MAP kinase-activated protein kinase 2 (Homo sapiens (Human))	BDBM50348512 (CHEMBL1801309) Show SMILES Fc1cccc(c1)-c1cc2-c3oc4c(c3CCc2cn1)C(=O)NCC41CNC1 Show InChI InChI=1S/C22H18FN3O2/c23-14-3-1-2-12(6-14)17-7-16-13(8-25-17)4-5-15-18-20(28-19(15)16)22(9-24-10-22)11-26-21(18)27/h1-3,6-8,24H,4-5,9-11H2,(H,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of MK2 mediated anisomycin-stimulated hsp27 phosphorylation in human THP-1 cells by fluorometric analysis				Bioorg Med Chem Lett 20: 4719-23 (2010) Checked by Author Article DOI: 10.1016/j.bmcl.2010.04.023 BindingDB Entry DOI: 10.7270/Q2BZ66C2
					More data for this Ligand-Target Pair
MAP kinase-activated protein kinase 2 (Homo sapiens (Human))	BDBM50348512 (CHEMBL1801309) Show SMILES Fc1cccc(c1)-c1cc2-c3oc4c(c3CCc2cn1)C(=O)NCC41CNC1 Show InChI InChI=1S/C22H18FN3O2/c23-14-3-1-2-12(6-14)17-7-16-13(8-25-17)4-5-15-18-20(28-19(15)16)22(9-24-10-22)11-26-21(18)27/h1-3,6-8,24H,4-5,9-11H2,(H,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of human MK2 using biotinyl-AYSRALSRQLSSGVSEIRCOOH as substrate after 45 mins by FRET analysis				Bioorg Med Chem Lett 20: 4719-23 (2010) Checked by Author Article DOI: 10.1016/j.bmcl.2010.04.023 BindingDB Entry DOI: 10.7270/Q2BZ66C2
					More data for this Ligand-Target Pair