BDBM50349140 CHEMBL1807713

SMILES: CN(C)Cc1cncc(c1)-c1ccc2[nH]c(nc2c1)-c1n[nH]c2ncc(cc12)N1CCN(C)CC1

InChI Key: InChIKey=JPQRTCXNCDUECH-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50349140   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM50349140 (CHEMBL1807713) Show SMILES CN(C)Cc1cncc(c1)-c1ccc2[nH]c(nc2c1)-c1n[nH]c2ncc(cc12)N1CCN(C)CC1 Show InChI InChI=1S/C26H29N9/c1-33(2)16-17-10-19(14-27-13-17)18-4-5-22-23(11-18)30-26(29-22)24-21-12-20(15-28-25(21)32-31-24)35-8-6-34(3)7-9-35/h4-5,10-15H,6-9,16H2,1-3H3,(H,29,30)(H,28,31,32)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	104	n/a	n/a	n/a	n/a	n/a	n/a
National Tsing Hua University Curated by ChEMBL					Assay Description Inhibition of RET kinase				Bioorg Med Chem Lett 21: 4490-7 (2011) Article DOI: 10.1016/j.bmcl.2011.06.003 BindingDB Entry DOI: 10.7270/Q2BV7H06
					More data for this Ligand-Target Pair