BDBM50350095 CHEMBL1813881

SMILES: Oc1c(Cl)cc(Cl)cc1C(=O)Nc1ccc(Oc2ccc3ccccc3c2)c(Cl)c1

InChI Key: InChIKey=UOMPUZXCBIRZNV-UHFFFAOYSA-N

Data: 2 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50350095   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
poly(ADP-ribose) glycohydrolase (PARG) (Homo sapiens (Human))	BDBM50350095 (CHEMBL1813881) Show SMILES Oc1c(Cl)cc(Cl)cc1C(=O)Nc1ccc(Oc2ccc3ccccc3c2)c(Cl)c1 Show InChI InChI=1S/C23H14Cl3NO3/c24-15-10-18(22(28)20(26)11-15)23(29)27-16-6-8-21(19(25)12-16)30-17-7-5-13-3-1-2-4-14(13)9-17/h1-12,28H,(H,27,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Arizona Curated by ChEMBL					Assay Description Inhibition of PARG using [alpha-32P]ADP-ribose polymers after 5 mins by TRAP assay				J Med Chem 54: 5403-13 (2011) Article DOI: 10.1021/jm200325s BindingDB Entry DOI: 10.7270/Q2416XFG
					More data for this Ligand-Target Pair
poly(ADP-ribose) glycohydrolase (PARG) (Homo sapiens (Human))	BDBM50350095 (CHEMBL1813881) Show SMILES Oc1c(Cl)cc(Cl)cc1C(=O)Nc1ccc(Oc2ccc3ccccc3c2)c(Cl)c1 Show InChI InChI=1S/C23H14Cl3NO3/c24-15-10-18(22(28)20(26)11-15)23(29)27-16-6-8-21(19(25)12-16)30-17-7-5-13-3-1-2-4-14(13)9-17/h1-12,28H,(H,27,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>7.00E+4	n/a	n/a	n/a	n/a
The University of Manchester Curated by ChEMBL					Assay Description Inhibition of human full length PARG using Bt-NAD ribosylated PARP1 substrate after 10 mins by TR-FRET assay				J Med Chem 61: 10767-10792 (2018) Article DOI: 10.1021/acs.jmedchem.8b01407 BindingDB Entry DOI: 10.7270/Q2TM7DTN
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM50350095 (CHEMBL1813881) Show SMILES Oc1c(Cl)cc(Cl)cc1C(=O)Nc1ccc(Oc2ccc3ccccc3c2)c(Cl)c1 Show InChI InChI=1S/C23H14Cl3NO3/c24-15-10-18(22(28)20(26)11-15)23(29)27-16-6-8-21(19(25)12-16)30-17-7-5-13-3-1-2-4-14(13)9-17/h1-12,28H,(H,27,29)	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Arizona Curated by ChEMBL					Assay Description Inhibition of PARP-1 using [32P]-NAD+ after 15 mins				J Med Chem 54: 5403-13 (2011) Article DOI: 10.1021/jm200325s BindingDB Entry DOI: 10.7270/Q2416XFG
					More data for this Ligand-Target Pair