BDBM50355880 CHEMBL1910024

SMILES: C[C@H](NC(=O)c1cccc2CCc3cc(ccc3Oc12)C(F)(F)F)c1ccc(cc1)C(O)=O

InChI Key: InChIKey=HJIUSIWRPBXBTB-AWEZNQCLSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50355880   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM50355880 (CHEMBL1910024) Show SMILES C[C@H](NC(=O)c1cccc2CCc3cc(ccc3Oc12)C(F)(F)F)c1ccc(cc1)C(O)=O |r| Show InChI InChI=1S/C25H20F3NO4/c1-14(15-5-8-17(9-6-15)24(31)32)29-23(30)20-4-2-3-16-7-10-18-13-19(25(26,27)28)11-12-21(18)33-22(16)20/h2-6,8-9,11-14H,7,10H2,1H3,(H,29,30)(H,31,32)/t14-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	42	n/a	n/a	n/a	n/a	n/a	n/a
Rottapharm Madaus Curated by ChEMBL					Assay Description Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by bead-based proximity ...				Bioorg Med Chem Lett 21: 6336-40 (2011) Article DOI: 10.1016/j.bmcl.2011.08.102 BindingDB Entry DOI: 10.7270/Q29Z95B1
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype (Homo sapiens (Human))	BDBM50355880 (CHEMBL1910024) Show SMILES C[C@H](NC(=O)c1cccc2CCc3cc(ccc3Oc12)C(F)(F)F)c1ccc(cc1)C(O)=O |r| Show InChI InChI=1S/C25H20F3NO4/c1-14(15-5-8-17(9-6-15)24(31)32)29-23(30)20-4-2-3-16-7-10-18-13-19(25(26,27)28)11-12-21(18)33-22(16)20/h2-6,8-9,11-14H,7,10H2,1H3,(H,29,30)(H,31,32)/t14-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Rottapharm Madaus Curated by ChEMBL					Assay Description Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells				Bioorg Med Chem Lett 21: 6336-40 (2011) Article DOI: 10.1016/j.bmcl.2011.08.102 BindingDB Entry DOI: 10.7270/Q29Z95B1
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM50355880 (CHEMBL1910024) Show SMILES C[C@H](NC(=O)c1cccc2CCc3cc(ccc3Oc12)C(F)(F)F)c1ccc(cc1)C(O)=O |r| Show InChI InChI=1S/C25H20F3NO4/c1-14(15-5-8-17(9-6-15)24(31)32)29-23(30)20-4-2-3-16-7-10-18-13-19(25(26,27)28)11-12-21(18)33-22(16)20/h2-6,8-9,11-14H,7,10H2,1H3,(H,29,30)(H,31,32)/t14-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	63	n/a	n/a	n/a	n/a	n/a	n/a
Rottapharm Madaus Curated by ChEMBL					Assay Description Displacement of [3H]-PGE2 from human EP4 receptor expressed in HEK293 cells				Bioorg Med Chem Lett 21: 6336-40 (2011) Article DOI: 10.1016/j.bmcl.2011.08.102 BindingDB Entry DOI: 10.7270/Q29Z95B1
					More data for this Ligand-Target Pair