null

SMILES: O=c1[nH]c(SCc2cccnc2C#N)c2COCCc2c1C#N

InChI Key: InChIKey=RMZOHPFYZBRDJW-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50356445   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50356445 (CHEMBL1911701) Show SMILES O=c1[nH]c(SCc2cccnc2C#N)c2COCCc2c1C#N Show InChI InChI=1S/C16H12N4O2S/c17-6-12-11-3-5-22-8-13(11)16(20-15(12)21)23-9-10-2-1-4-19-14(10)7-18/h1-2,4H,3,5,8-9H2,(H,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Research& Development Curated by ChEMBL					Assay Description Inhibition of human 11beta-HSD1 expressed in HEK293 cells assessed as conversion of [3H]-cortisone to [3H]-cortisol by scintillation plate reader				Bioorg Med Chem Lett 21: 6693-8 (2011) Article DOI: 10.1016/j.bmcl.2011.09.058 BindingDB Entry DOI: 10.7270/Q2FN16M4
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50356445 (CHEMBL1911701) Show SMILES O=c1[nH]c(SCc2cccnc2C#N)c2COCCc2c1C#N Show InChI InChI=1S/C16H12N4O2S/c17-6-12-11-3-5-22-8-13(11)16(20-15(12)21)23-9-10-2-1-4-19-14(10)7-18/h1-2,4H,3,5,8-9H2,(H,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	270	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Research& Development Curated by ChEMBL					Assay Description Inhibition of 11beta-HSD1 in human HEK cells				Bioorg Med Chem Lett 21: 6693-8 (2011) Article DOI: 10.1016/j.bmcl.2011.09.058 BindingDB Entry DOI: 10.7270/Q2FN16M4
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Mus musculus (mouse))	BDBM50356445 (CHEMBL1911701) Show SMILES O=c1[nH]c(SCc2cccnc2C#N)c2COCCc2c1C#N Show InChI InChI=1S/C16H12N4O2S/c17-6-12-11-3-5-22-8-13(11)16(20-15(12)21)23-9-10-2-1-4-19-14(10)7-18/h1-2,4H,3,5,8-9H2,(H,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.97E+3	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Research& Development Curated by ChEMBL					Assay Description Inhibition of 11beta-HSD1 in mouse 3T3L1 cells				Bioorg Med Chem Lett 21: 6693-8 (2011) Article DOI: 10.1016/j.bmcl.2011.09.058 BindingDB Entry DOI: 10.7270/Q2FN16M4
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Mus musculus (mouse))	BDBM50356445 (CHEMBL1911701) Show SMILES O=c1[nH]c(SCc2cccnc2C#N)c2COCCc2c1C#N Show InChI InChI=1S/C16H12N4O2S/c17-6-12-11-3-5-22-8-13(11)16(20-15(12)21)23-9-10-2-1-4-19-14(10)7-18/h1-2,4H,3,5,8-9H2,(H,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	105	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Research& Development Curated by ChEMBL					Assay Description Inhibition of mouse 11beta-HSD1				Bioorg Med Chem Lett 21: 6693-8 (2011) Article DOI: 10.1016/j.bmcl.2011.09.058 BindingDB Entry DOI: 10.7270/Q2FN16M4
					More data for this Ligand-Target Pair