null

SMILES: COc1cc(cc2n(Cc3ccc(cc3)C(=O)Nc3nnn[nH]3)c(=Nc3ccc(OC(F)(F)F)cc3)n(C)c12)C(F)(F)F

InChI Key: InChIKey=QOCSOYLFZWXWJI-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50358364   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glucagon receptor (Homo sapiens (Human))	BDBM50358364 (CHEMBL1922712) Show SMILES COc1cc(cc2n(Cc3ccc(cc3)C(=O)Nc3nnn[nH]3)c(=Nc3ccc(OC(F)(F)F)cc3)n(C)c12)C(F)(F)F |w:24.26| Show InChI InChI=1S/C26H20F6N8O3/c1-39-21-19(11-16(25(27,28)29)12-20(21)42-2)40(24(39)33-17-7-9-18(10-8-17)43-26(30,31)32)13-14-3-5-15(6-4-14)22(41)34-23-35-37-38-36-23/h3-12H,13H2,1-2H3,(H2,34,35,36,37,38,41)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	8.30	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Displacement of [125I]glucagon from human GCGR expressed in CHO cells after 4 to 12 hrs by scintillation counting				Bioorg Med Chem Lett 21: 7131-6 (2011) Article DOI: 10.1016/j.bmcl.2011.09.085 BindingDB Entry DOI: 10.7270/Q2C829QP
					More data for this Ligand-Target Pair
Glucagon receptor (Homo sapiens (Human))	BDBM50358364 (CHEMBL1922712) Show SMILES COc1cc(cc2n(Cc3ccc(cc3)C(=O)Nc3nnn[nH]3)c(=Nc3ccc(OC(F)(F)F)cc3)n(C)c12)C(F)(F)F |w:24.26| Show InChI InChI=1S/C26H20F6N8O3/c1-39-21-19(11-16(25(27,28)29)12-20(21)42-2)40(24(39)33-17-7-9-18(10-8-17)43-26(30,31)32)13-14-3-5-15(6-4-14)22(41)34-23-35-37-38-36-23/h3-12H,13H2,1-2H3,(H2,34,35,36,37,38,41)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	41	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Antagonist activity at human GCGR expressed in CHO cells assessed as inhibition of glucagon-induced [125I]cAMP accumulation after 30 mins by scintill...				Bioorg Med Chem Lett 21: 7131-6 (2011) Article DOI: 10.1016/j.bmcl.2011.09.085 BindingDB Entry DOI: 10.7270/Q2C829QP
					More data for this Ligand-Target Pair