Found 3 hits for monomerid = 50358561 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50358561
(CHEMBL1923664)Show SMILES NC(N)=NCCC[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CCCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCNC(=O)CCCC#C)C(N)=O |r,wU:22.30,11.19,7.7,wD:44.46,62.66,(14.73,6.99,;16.06,6.21,;17.4,6.98,;16.06,4.67,;14.72,3.9,;14.72,2.37,;13.39,1.59,;13.39,.06,;12.05,-.71,;10.71,.06,;10.71,1.6,;9.39,-.7,;9.39,-2.25,;10.71,-3.02,;12.05,-2.25,;13.38,-3.03,;13.38,-4.57,;12.04,-5.33,;10.71,-4.56,;8.05,.06,;6.72,-.7,;6.72,-2.24,;5.38,.06,;5.38,1.61,;6.72,2.38,;8.2,1.91,;9.08,3.17,;8.16,4.41,;6.7,3.91,;4.05,-.7,;2.72,.06,;2.71,1.6,;1.38,-.71,;.05,.06,;-1.29,-.71,;-2.61,.05,;-2.62,1.59,;-3.94,2.37,;-5.28,1.59,;-5.28,.04,;-3.93,-.72,;14.72,-.71,;14.72,-2.26,;16.06,.05,;17.39,-.72,;17.39,-2.26,;18.71,-3.03,;19.97,-2.13,;21.21,-3.05,;20.73,-4.51,;21.49,-5.84,;20.72,-7.18,;19.18,-7.17,;18.41,-5.83,;19.19,-4.5,;18.71,.05,;18.71,1.59,;20.06,-.72,;21.39,.05,;22.73,-.71,;22.73,-2.25,;24.06,.05,;25.4,-.71,;25.4,-2.25,;26.73,-3.02,;26.73,-4.56,;28.07,-5.33,;28.07,-6.87,;26.74,-7.64,;25.4,-6.87,;26.74,-9.18,;25.4,-9.95,;25.4,-11.49,;24.07,-12.27,;22.73,-13.02,;26.73,.06,;28.06,-.71,;26.73,1.6,)| Show InChI InChI=1S/C56H72N14O8/c1-2-3-6-26-48(71)61-28-14-13-24-43(51(57)74)66-50(73)35-64-52(75)46(31-39-33-63-42-23-12-11-22-41(39)42)70-53(76)44(25-16-29-62-56(58)59)68-54(77)45(30-38-19-9-5-10-20-38)69-55(78)47(32-40-34-60-36-65-40)67-49(72)27-15-21-37-17-7-4-8-18-37/h1,4-5,7-12,17-20,22-23,33-34,36,43-47,63H,3,6,13-16,21,24-32,35H2,(H2,57,74)(H,60,65)(H,61,71)(H,64,75)(H,66,73)(H,67,72)(H,68,77)(H,69,78)(H,70,76)(H4,58,59,62)/t43-,44-,45+,46-,47-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.240 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
H. Lee Moffitt Cancer Center& Research Institute
Curated by ChEMBL
| Assay Description
Displacement of Eu-NDP-alphaMSH from human MC1 receptor expressed in human HCT116 cells after 1.5 hrs by time-resolved fluorescence analysis |
J Med Chem 54: 8078-84 (2011)
Article DOI: 10.1021/jm201226w
BindingDB Entry DOI: 10.7270/Q2G1618K |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 5
(Homo sapiens (Human)) | BDBM50358561
(CHEMBL1923664)Show SMILES NC(N)=NCCC[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CCCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCNC(=O)CCCC#C)C(N)=O |r,wU:22.30,11.19,7.7,wD:44.46,62.66,(14.73,6.99,;16.06,6.21,;17.4,6.98,;16.06,4.67,;14.72,3.9,;14.72,2.37,;13.39,1.59,;13.39,.06,;12.05,-.71,;10.71,.06,;10.71,1.6,;9.39,-.7,;9.39,-2.25,;10.71,-3.02,;12.05,-2.25,;13.38,-3.03,;13.38,-4.57,;12.04,-5.33,;10.71,-4.56,;8.05,.06,;6.72,-.7,;6.72,-2.24,;5.38,.06,;5.38,1.61,;6.72,2.38,;8.2,1.91,;9.08,3.17,;8.16,4.41,;6.7,3.91,;4.05,-.7,;2.72,.06,;2.71,1.6,;1.38,-.71,;.05,.06,;-1.29,-.71,;-2.61,.05,;-2.62,1.59,;-3.94,2.37,;-5.28,1.59,;-5.28,.04,;-3.93,-.72,;14.72,-.71,;14.72,-2.26,;16.06,.05,;17.39,-.72,;17.39,-2.26,;18.71,-3.03,;19.97,-2.13,;21.21,-3.05,;20.73,-4.51,;21.49,-5.84,;20.72,-7.18,;19.18,-7.17,;18.41,-5.83,;19.19,-4.5,;18.71,.05,;18.71,1.59,;20.06,-.72,;21.39,.05,;22.73,-.71,;22.73,-2.25,;24.06,.05,;25.4,-.71,;25.4,-2.25,;26.73,-3.02,;26.73,-4.56,;28.07,-5.33,;28.07,-6.87,;26.74,-7.64,;25.4,-6.87,;26.74,-9.18,;25.4,-9.95,;25.4,-11.49,;24.07,-12.27,;22.73,-13.02,;26.73,.06,;28.06,-.71,;26.73,1.6,)| Show InChI InChI=1S/C56H72N14O8/c1-2-3-6-26-48(71)61-28-14-13-24-43(51(57)74)66-50(73)35-64-52(75)46(31-39-33-63-42-23-12-11-22-41(39)42)70-53(76)44(25-16-29-62-56(58)59)68-54(77)45(30-38-19-9-5-10-20-38)69-55(78)47(32-40-34-60-36-65-40)67-49(72)27-15-21-37-17-7-4-8-18-37/h1,4-5,7-12,17-20,22-23,33-34,36,43-47,63H,3,6,13-16,21,24-32,35H2,(H2,57,74)(H,60,65)(H,61,71)(H,64,75)(H,66,73)(H,67,72)(H,68,77)(H,69,78)(H,70,76)(H4,58,59,62)/t43-,44-,45+,46-,47-/m0/s1 | UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 46 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
H. Lee Moffitt Cancer Center& Research Institute
Curated by ChEMBL
| Assay Description
Displacement of Eu-NDP-alphaMSH from human MC5 receptor expressed in human HEK293 cells after 1.5 hrs by time-resolved fluorescence analysis |
J Med Chem 54: 8078-84 (2011)
Article DOI: 10.1021/jm201226w
BindingDB Entry DOI: 10.7270/Q2G1618K |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50358561
(CHEMBL1923664)Show SMILES NC(N)=NCCC[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CCCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCNC(=O)CCCC#C)C(N)=O |r,wU:22.30,11.19,7.7,wD:44.46,62.66,(14.73,6.99,;16.06,6.21,;17.4,6.98,;16.06,4.67,;14.72,3.9,;14.72,2.37,;13.39,1.59,;13.39,.06,;12.05,-.71,;10.71,.06,;10.71,1.6,;9.39,-.7,;9.39,-2.25,;10.71,-3.02,;12.05,-2.25,;13.38,-3.03,;13.38,-4.57,;12.04,-5.33,;10.71,-4.56,;8.05,.06,;6.72,-.7,;6.72,-2.24,;5.38,.06,;5.38,1.61,;6.72,2.38,;8.2,1.91,;9.08,3.17,;8.16,4.41,;6.7,3.91,;4.05,-.7,;2.72,.06,;2.71,1.6,;1.38,-.71,;.05,.06,;-1.29,-.71,;-2.61,.05,;-2.62,1.59,;-3.94,2.37,;-5.28,1.59,;-5.28,.04,;-3.93,-.72,;14.72,-.71,;14.72,-2.26,;16.06,.05,;17.39,-.72,;17.39,-2.26,;18.71,-3.03,;19.97,-2.13,;21.21,-3.05,;20.73,-4.51,;21.49,-5.84,;20.72,-7.18,;19.18,-7.17,;18.41,-5.83,;19.19,-4.5,;18.71,.05,;18.71,1.59,;20.06,-.72,;21.39,.05,;22.73,-.71,;22.73,-2.25,;24.06,.05,;25.4,-.71,;25.4,-2.25,;26.73,-3.02,;26.73,-4.56,;28.07,-5.33,;28.07,-6.87,;26.74,-7.64,;25.4,-6.87,;26.74,-9.18,;25.4,-9.95,;25.4,-11.49,;24.07,-12.27,;22.73,-13.02,;26.73,.06,;28.06,-.71,;26.73,1.6,)| Show InChI InChI=1S/C56H72N14O8/c1-2-3-6-26-48(71)61-28-14-13-24-43(51(57)74)66-50(73)35-64-52(75)46(31-39-33-63-42-23-12-11-22-41(39)42)70-53(76)44(25-16-29-62-56(58)59)68-54(77)45(30-38-19-9-5-10-20-38)69-55(78)47(32-40-34-60-36-65-40)67-49(72)27-15-21-37-17-7-4-8-18-37/h1,4-5,7-12,17-20,22-23,33-34,36,43-47,63H,3,6,13-16,21,24-32,35H2,(H2,57,74)(H,60,65)(H,61,71)(H,64,75)(H,66,73)(H,67,72)(H,68,77)(H,69,78)(H,70,76)(H4,58,59,62)/t43-,44-,45+,46-,47-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 254 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
H. Lee Moffitt Cancer Center& Research Institute
Curated by ChEMBL
| Assay Description
Displacement of Eu-NDP-alphaMSH from human MC4 receptor expressed in human HEK293 cells after 1.5 hrs by time-resolved fluorescence analysis |
J Med Chem 54: 8078-84 (2011)
Article DOI: 10.1021/jm201226w
BindingDB Entry DOI: 10.7270/Q2G1618K |
More data for this
Ligand-Target Pair | |
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