BindingDB PrimarySearch

BDBM50362690 CHEMBL1829173

SMILES: CC#C[C@@H](CC(O)=O)c1ccc(OCc2cccc(c2)-c2ccc(cc2)C(F)(F)F)cc1

InChI Key: InChIKey=ZOPNBMMVVZRSGH-NRFANRHFSA-N

Data: 1 KI 17 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 26 hits for monomerid = 50362690
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM50362690 (AMG-837 \| CHEMBL1829173) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars		2.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM50362690 (AMG-837 \| CHEMBL1829173) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	42	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Southern Denmark Curated by ChEMBL					Assay Description Displacement of 3-(2-Fluoro-4-((2'-methyl-4'-(2-(2-((7-nitrobenzo[c][1,2,5]-oxadiazol-4-yl)amino)ethoxy)ethoxy)-[1,1'-biphenyl]-3-yl)-methoxy)phenyl)...				J Med Chem 59: 4849-58 (2016) BindingDB Entry DOI: 10.7270/Q24T6M9W
University of Southern Denmark Curated by ChEMBL					More data for this Ligand-Target Pair
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM50362690 (AMG-837 \| CHEMBL1829173) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	8.80E+3	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 100% human seru...				Bioorg Med Chem Lett 26: 15-20 (2015) BindingDB Entry DOI: 10.7270/Q21R6SBS
Amgen Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM50362690 (AMG-837 \| CHEMBL1829173) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	80	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human ser...				Bioorg Med Chem Lett 26: 15-20 (2015) BindingDB Entry DOI: 10.7270/Q21R6SBS
Amgen Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM50362690 (AMG-837 \| CHEMBL1829173) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	13	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis				Bioorg Med Chem Lett 26: 15-20 (2015) BindingDB Entry DOI: 10.7270/Q21R6SBS
Amgen Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM50362690 (AMG-837 \| CHEMBL1829173) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	155	n/a	n/a	n/a	n/a
University of Southern Denmark Curated by ChEMBL					Assay Description Agonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins...				J Med Chem 59: 4849-58 (2016) BindingDB Entry DOI: 10.7270/Q24T6M9W
University of Southern Denmark Curated by ChEMBL					More data for this Ligand-Target Pair
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM50362690 (AMG-837 \| CHEMBL1829173) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	170	n/a	n/a	n/a	n/a
University of Southern Denmark Curated by ChEMBL					Assay Description Agonist activity at FFA1 receptor (unknown origin) expressed in human 132N1 cells measured for 90 secs by Fura-2 AM dye based calcium mobilization as...				J Med Chem 59: 4849-58 (2016) BindingDB Entry DOI: 10.7270/Q24T6M9W
University of Southern Denmark Curated by ChEMBL					More data for this Ligand-Target Pair
Free fatty acid receptor 1 (Rattus norvegicus)	BDBM50362690 (AMG-837 \| CHEMBL1829173) Show SMILES Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	23	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Agonist activity at rat GPR40				Bioorg Med Chem Lett 22: 1267-70 (2012) Article DOI: 10.1016/j.bmcl.2011.10.118 BindingDB Entry DOI: 10.7270/Q2MC90GP
Amgen Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Free fatty acid receptor 1 (Mus musculus)	BDBM50362690 (AMG-837 \| CHEMBL1829173) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	13	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Agonist activity at mouse GPR40				Bioorg Med Chem Lett 22: 1267-70 (2012) Article DOI: 10.1016/j.bmcl.2011.10.118 BindingDB Entry DOI: 10.7270/Q2MC90GP
Amgen Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM50362690 (AMG-837 \| CHEMBL1829173) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	25	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assay				Bioorg Med Chem Lett 22: 1267-70 (2012) Article DOI: 10.1016/j.bmcl.2011.10.118 BindingDB Entry DOI: 10.7270/Q2MC90GP
Amgen Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM50362690 (AMG-837 \| CHEMBL1829173) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	13	n/a	n/a	n/a	n/a
Shanghai University Curated by ChEMBL					Assay Description Agonist activity at GPR40 (unknown origin) by calcium flux assay				Bioorg Med Chem Lett 26: 5603-5612 (2016) Article DOI: 10.1016/j.bmcl.2016.10.074 BindingDB Entry DOI: 10.7270/Q2C82C94
Shanghai University Curated by ChEMBL					More data for this Ligand-Target Pair
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM50362690 (AMG-837 \| CHEMBL1829173) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	23	n/a	n/a	n/a	n/a
Saint Petersburg State University Curated by ChEMBL					Assay Description Agonist activity at FFA1 receptor (unknown origin)				Bioorg Med Chem 24: 5481-5494 (2016) Article DOI: 10.1016/j.bmc.2016.09.004 BindingDB Entry DOI: 10.7270/Q2BR8V4G
Saint Petersburg State University Curated by ChEMBL					More data for this Ligand-Target Pair
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM50362690 (AMG-837 \| CHEMBL1829173) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	2.20	n/a	n/a	n/a	n/a
Cadila Healthcare Ltd. Curated by ChEMBL					Assay Description Agonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assay				ACS Med Chem Lett 7: 1134-1138 (2016) Article DOI: 10.1021/acsmedchemlett.6b00331 BindingDB Entry DOI: 10.7270/Q2K35WN3
Cadila Healthcare Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM50362690 (AMG-837 \| CHEMBL1829173) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	60	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Agonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assay				ACS Med Chem Lett 4: 551-5 (2013) Article DOI: 10.1021/ml300427u BindingDB Entry DOI: 10.7270/Q2G16263
Amgen Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM50362690 (AMG-837 \| CHEMBL1829173) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	100	n/a	n/a	n/a	n/a
University of Southern Denmark Curated by ChEMBL					Assay Description Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry				J Med Chem 54: 6691-703 (2011) Article DOI: 10.1021/jm2005699 BindingDB Entry DOI: 10.7270/Q25T3MRW
University of Southern Denmark Curated by ChEMBL					More data for this Ligand-Target Pair
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM50362690 (AMG-837 \| CHEMBL1829173) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	60	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum				ACS Med Chem Lett 3: 726-730 (2012) Article DOI: 10.1021/ml300133f BindingDB Entry DOI: 10.7270/Q2TQ62MG
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM50362690 (AMG-837 \| CHEMBL1829173) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	13	n/a	n/a	n/a	n/a
Guangdong Pharmaceutical University Curated by ChEMBL					Assay Description Agonist activity at FFA1 (unknown origin)				Eur J Med Chem 159: 267-276 (2018) Article DOI: 10.1016/j.ejmech.2018.09.071 BindingDB Entry DOI: 10.7270/Q27D2XTM
Guangdong Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair
Replicase polyprotein 1ab (2019-nCoV)	BDBM50362690 (AMG-837 \| CHEMBL1829173) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars		n/a	n/a	2.42E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM50362690 (AMG-837 \| CHEMBL1829173) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars		n/a	n/a	n/a	n/a	15	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM50362690 (AMG-837 \| CHEMBL1829173) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars		n/a	n/a	n/a	n/a	11	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Free fatty acid receptor 1 (Mus musculus)	BDBM50362690 (AMG-837 \| CHEMBL1829173) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars		n/a	n/a	n/a	n/a	1.5	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Rattus norvegicus)	BDBM50362690 (AMG-837 \| CHEMBL1829173) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars		n/a	n/a	n/a	n/a	3.20	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM50362690 (AMG-837 \| CHEMBL1829173) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars		n/a	n/a	n/a	n/a	1.30	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM50362690 (AMG-837 \| CHEMBL1829173) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars		n/a	n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM50362690 (AMG-837 \| CHEMBL1829173) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	104	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Agonist activity at human GPR40 expressed in CHO cells by aequorin assay				ACS Med Chem Lett 5: 517-21 (2014) Article DOI: 10.1021/ml400501x BindingDB Entry DOI: 10.7270/Q2028T3M
Amgen Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM50362690 (AMG-837 \| CHEMBL1829173) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	41	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Agonist activity at human GPR40 expressed in mouse A9 cells by inositol phosphate accumulation assay				ACS Med Chem Lett 5: 517-21 (2014) Article DOI: 10.1021/ml400501x BindingDB Entry DOI: 10.7270/Q2028T3M
Amgen Inc. Curated by ChEMBL					More data for this Ligand-Target Pair