null

SMILES: COc1ccc(CNC2=NC(=O)C(N2)=C2CCNC(=O)c3[nH]c(cc23)-c2ccccc2)cc1

InChI Key: InChIKey=PRWHEVDDTCYVMS-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50363650   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase Chk2 (Homo sapiens (Human))	BDBM50363650 (CHEMBL1947254) Show SMILES COc1ccc(CNC2=NC(=O)C(N2)=C2CCNC(=O)c3[nH]c(cc23)-c2ccccc2)cc1 |w:14.15,t:8| Show InChI InChI=1S/C25H23N5O3/c1-33-17-9-7-15(8-10-17)14-27-25-29-21(24(32)30-25)18-11-12-26-23(31)22-19(18)13-20(28-22)16-5-3-2-4-6-16/h2-10,13,28H,11-12,14H2,1H3,(H,26,31)(H2,27,29,30,32)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	588	n/a	n/a	n/a	n/a	n/a	n/a
Michigan State University Curated by ChEMBL					Assay Description Inhibition of human Chk2 using STK1 as substrate after 10 mins by HTRF assay				Bioorg Med Chem 20: 1475-81 (2012) Article DOI: 10.1016/j.bmc.2011.12.054 BindingDB Entry DOI: 10.7270/Q20865RK
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM50363650 (CHEMBL1947254) Show SMILES COc1ccc(CNC2=NC(=O)C(N2)=C2CCNC(=O)c3[nH]c(cc23)-c2ccccc2)cc1 |w:14.15,t:8| Show InChI InChI=1S/C25H23N5O3/c1-33-17-9-7-15(8-10-17)14-27-25-29-21(24(32)30-25)18-11-12-26-23(31)22-19(18)13-20(28-22)16-5-3-2-4-6-16/h2-10,13,28H,11-12,14H2,1H3,(H,26,31)(H2,27,29,30,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Michigan State University Curated by ChEMBL					Assay Description Inhibition of human CHK1 using STK1 as substrate after 10 mins by HTRF assay				Bioorg Med Chem 20: 1475-81 (2012) Article DOI: 10.1016/j.bmc.2011.12.054 BindingDB Entry DOI: 10.7270/Q20865RK
					More data for this Ligand-Target Pair