BDBM50365240 CHEMBL1956272

SMILES: Cc1cc(Nc2ccc(cc2)C(F)(F)F)n2nc(nc2n1)C(C)(C)C

InChI Key: InChIKey=NTDAVEUJPUHTMJ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50365240   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dihydroorotate dehydrogenase (Homo sapiens (Human))	BDBM50365240 (CHEMBL1956272) Show SMILES Cc1cc(Nc2ccc(cc2)C(F)(F)F)n2nc(nc2n1)C(C)(C)C Show InChI InChI=1S/C17H18F3N5/c1-10-9-13(22-12-7-5-11(6-8-12)17(18,19)20)25-15(21-10)23-14(24-25)16(2,3)4/h5-9,22H,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of human C-terminal hexa-His tagged DHODH expressed in Escherichia coli by DCIP reduction assay				J Med Chem 54: 5540-61 (2011) Article DOI: 10.1021/jm200592f BindingDB Entry DOI: 10.7270/Q21N81M0
					More data for this Ligand-Target Pair