BDBM50372525 CHEMBL270584

SMILES: COc1cnc2c3NS(=O)(=O)c4ccccc4-c3ccc2c1

InChI Key: InChIKey=PAGUEXPGJGKHKX-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50372525   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Nuclear factor NF-kappa-B (Homo sapiens (Human))	BDBM50372525 (CHEMBL270584) Show SMILES COc1cnc2c3NS(=O)(=O)c4ccccc4-c3ccc2c1 Show InChI InChI=1S/C16H12N2O3S/c1-21-11-8-10-6-7-13-12-4-2-3-5-14(12)22(19,20)18-16(13)15(10)17-9-11/h2-9,18H,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Columbia University Curated by ChEMBL					Assay Description Inhibition of TNF-alpha-stimulated human NF-kappaB p65 RelA subunit nuclear translocation in HUVEC				Bioorg Med Chem Lett 18: 329-35 (2008) Article DOI: 10.1016/j.bmcl.2007.10.100 BindingDB Entry DOI: 10.7270/Q2348M63
					More data for this Ligand-Target Pair