BDBM50377726 CHEMBL257129

SMILES: Cn1c(nnc1-c1cc2ccccc2cc1Cl)-c1ccccc1C(F)(F)F

InChI Key: InChIKey=POYZNCSBPDZNDU-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50377726   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
11-beta-hydroxysteroid dehydrogenase 1 (Mus musculus (mouse))	BDBM50377726 (CHEMBL257129) Show SMILES Cn1c(nnc1-c1cc2ccccc2cc1Cl)-c1ccccc1C(F)(F)F Show InChI InChI=1S/C20H13ClF3N3/c1-27-18(14-8-4-5-9-16(14)20(22,23)24)25-26-19(27)15-10-12-6-2-3-7-13(12)11-17(15)21/h2-11H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.80	n/a	n/a	n/a	n/a	n/a	n/a
Merck& Co. Curated by ChEMBL					Assay Description Inhibition of mouse 11beta-HSD1 expressed in CHO-K1 cells				Bioorg Med Chem Lett 18: 2799-804 (2008) Article DOI: 10.1016/j.bmcl.2008.04.010 BindingDB Entry DOI: 10.7270/Q2J9678F
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50377726 (CHEMBL257129) Show SMILES Cn1c(nnc1-c1cc2ccccc2cc1Cl)-c1ccccc1C(F)(F)F Show InChI InChI=1S/C20H13ClF3N3/c1-27-18(14-8-4-5-9-16(14)20(22,23)24)25-26-19(27)15-10-12-6-2-3-7-13(12)11-17(15)21/h2-11H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.90	n/a	n/a	n/a	n/a	n/a	n/a
Merck& Co. Curated by ChEMBL					Assay Description Inhibition of human 11beta-HSD1 expressed in CHO-K1 cells				Bioorg Med Chem Lett 18: 2799-804 (2008) Article DOI: 10.1016/j.bmcl.2008.04.010 BindingDB Entry DOI: 10.7270/Q2J9678F
					More data for this Ligand-Target Pair