BDBM50379987 CHEMBL2012238

SMILES: COc1ccc(-c2nc(C(=O)N[C@H](CO)c3ccccc3)c(o2)[C@@H](C)N)c2ccc(nc12)C(F)(F)F

InChI Key: InChIKey=CSRHBOSHJUKGAS-CXAGYDPISA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50379987   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50379987 (CHEMBL2012238) Show SMILES COc1ccc(-c2nc(C(=O)N[C@H](CO)c3ccccc3)c(o2)[C@@H](C)N)c2ccc(nc12)C(F)(F)F |r| Show InChI InChI=1S/C25H23F3N4O4/c1-13(29)22-21(23(34)30-17(12-33)14-6-4-3-5-7-14)32-24(36-22)16-8-10-18(35-2)20-15(16)9-11-19(31-20)25(26,27)28/h3-11,13,17,33H,12,29H2,1-2H3,(H,30,34)/t13-,17-/m1/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.40	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of PDE4B				Bioorg Med Chem Lett 22: 2594-7 (2012) Article DOI: 10.1016/j.bmcl.2012.01.115 BindingDB Entry DOI: 10.7270/Q2CN74X0
					More data for this Ligand-Target Pair