null

SMILES: Nc1nc2ccccc2c2n(Cc3ccccc3)c(CCCCCCCCCCc3nc4c(N)nc5ccccc5c4n3Cc3ccccc3)nc12

InChI Key: InChIKey=DIBFYNLRFHMPNT-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50380504   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50380504 (CHEMBL2018891) Show SMILES Nc1nc2ccccc2c2n(Cc3ccccc3)c(CCCCCCCCCCc3nc4c(N)nc5ccccc5c4n3Cc3ccccc3)nc12 Show InChI InChI=1S/C44H46N8/c45-43-39-41(33-23-15-17-25-35(33)47-43)51(29-31-19-9-7-10-20-31)37(49-39)27-13-5-3-1-2-4-6-14-28-38-50-40-42(52(38)30-32-21-11-8-12-22-32)34-24-16-18-26-36(34)48-44(40)46/h7-12,15-26H,1-6,13-14,27-30H2,(H2,45,47)(H2,46,48)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.65E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Kansas Curated by ChEMBL					Assay Description Antagonist activity at human TLR8 expressed in HEK-Blue cells assessed as inhibition of CL075-induced NFkappaB activation by sAP reporter gene assay				J Med Chem 55: 1106-16 (2012) Article DOI: 10.1021/jm2010207 BindingDB Entry DOI: 10.7270/Q2VH5PVX
					More data for this Ligand-Target Pair
Toll-like receptor 7 (Homo sapiens (Human))	BDBM50380504 (CHEMBL2018891) Show SMILES Nc1nc2ccccc2c2n(Cc3ccccc3)c(CCCCCCCCCCc3nc4c(N)nc5ccccc5c4n3Cc3ccccc3)nc12 Show InChI InChI=1S/C44H46N8/c45-43-39-41(33-23-15-17-25-35(33)47-43)51(29-31-19-9-7-10-20-31)37(49-39)27-13-5-3-1-2-4-6-14-28-38-50-40-42(52(38)30-32-21-11-8-12-22-32)34-24-16-18-26-36(34)48-44(40)46/h7-12,15-26H,1-6,13-14,27-30H2,(H2,45,47)(H2,46,48)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.79E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Kansas Curated by ChEMBL					Assay Description Antagonist activity at human TLR7 expressed in HEK-Blue cells assessed as inhibition of gardiquimod-induced NFkappaB activation by sAP reporter gene ...				J Med Chem 55: 1106-16 (2012) Article DOI: 10.1021/jm2010207 BindingDB Entry DOI: 10.7270/Q2VH5PVX
					More data for this Ligand-Target Pair