Found 4 hits for monomerid = 50382936 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50382936
(CHEMBL2029571)Show SMILES O[C@]1(CC[C@@H](CC1)N[C@H]1CCN(C1)C(=O)C1CCN(CC1)c1cc(ccn1)C#N)c1ccc(cn1)-c1ncccn1 |r,wU:4.7,wD:1.0,8.8,(26.18,-29.46,;27.52,-30.23,;28.85,-30.99,;30.18,-30.23,;30.18,-28.69,;28.85,-27.91,;27.52,-28.69,;31.51,-27.93,;32.84,-28.7,;32.86,-30.23,;34.33,-30.69,;35.22,-29.43,;34.3,-28.2,;36.55,-28.66,;36.54,-27.12,;37.89,-29.42,;37.89,-30.95,;39.22,-31.71,;40.56,-30.94,;40.55,-29.39,;39.21,-28.63,;41.89,-31.7,;43.21,-30.92,;44.55,-31.68,;44.56,-33.23,;43.23,-34,;41.89,-33.24,;45.88,-30.9,;47.2,-30.12,;26.19,-31,;24.85,-30.23,;23.52,-31,;23.52,-32.55,;24.87,-33.31,;26.19,-32.54,;22.19,-33.32,;20.86,-32.56,;19.53,-33.33,;19.53,-34.87,;20.88,-35.64,;22.2,-34.86,)| Show InChI InChI=1S/C31H36N8O2/c32-19-22-6-14-33-28(18-22)38-15-7-23(8-16-38)30(40)39-17-9-26(21-39)37-25-4-10-31(41,11-5-25)27-3-2-24(20-36-27)29-34-12-1-13-35-29/h1-3,6,12-14,18,20,23,25-26,37,41H,4-5,7-11,15-17,21H2/t25-,26-,31-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Displacement of [3H]dofetilide from human ERG |
ACS Med Chem Lett 2: 913-918 (2011)
Article DOI: 10.1021/ml200199c
BindingDB Entry DOI: 10.7270/Q29024TK |
More data for this
Ligand-Target Pair | |
C-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50382936
(CHEMBL2029571)Show SMILES O[C@]1(CC[C@@H](CC1)N[C@H]1CCN(C1)C(=O)C1CCN(CC1)c1cc(ccn1)C#N)c1ccc(cn1)-c1ncccn1 |r,wU:4.7,wD:1.0,8.8,(26.18,-29.46,;27.52,-30.23,;28.85,-30.99,;30.18,-30.23,;30.18,-28.69,;28.85,-27.91,;27.52,-28.69,;31.51,-27.93,;32.84,-28.7,;32.86,-30.23,;34.33,-30.69,;35.22,-29.43,;34.3,-28.2,;36.55,-28.66,;36.54,-27.12,;37.89,-29.42,;37.89,-30.95,;39.22,-31.71,;40.56,-30.94,;40.55,-29.39,;39.21,-28.63,;41.89,-31.7,;43.21,-30.92,;44.55,-31.68,;44.56,-33.23,;43.23,-34,;41.89,-33.24,;45.88,-30.9,;47.2,-30.12,;26.19,-31,;24.85,-30.23,;23.52,-31,;23.52,-32.55,;24.87,-33.31,;26.19,-32.54,;22.19,-33.32,;20.86,-32.56,;19.53,-33.33,;19.53,-34.87,;20.88,-35.64,;22.2,-34.86,)| Show InChI InChI=1S/C31H36N8O2/c32-19-22-6-14-33-28(18-22)38-15-7-23(8-16-38)30(40)39-17-9-26(21-39)37-25-4-10-31(41,11-5-25)27-3-2-24(20-36-27)29-34-12-1-13-35-29/h1-3,6,12-14,18,20,23,25-26,37,41H,4-5,7-11,15-17,21H2/t25-,26-,31-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCP1 from human CCR2 in PBMC after 30 mins by gamma counting |
ACS Med Chem Lett 2: 913-918 (2011)
Article DOI: 10.1021/ml200199c
BindingDB Entry DOI: 10.7270/Q29024TK |
More data for this
Ligand-Target Pair | |
C-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50382936
(CHEMBL2029571)Show SMILES O[C@]1(CC[C@@H](CC1)N[C@H]1CCN(C1)C(=O)C1CCN(CC1)c1cc(ccn1)C#N)c1ccc(cn1)-c1ncccn1 |r,wU:4.7,wD:1.0,8.8,(26.18,-29.46,;27.52,-30.23,;28.85,-30.99,;30.18,-30.23,;30.18,-28.69,;28.85,-27.91,;27.52,-28.69,;31.51,-27.93,;32.84,-28.7,;32.86,-30.23,;34.33,-30.69,;35.22,-29.43,;34.3,-28.2,;36.55,-28.66,;36.54,-27.12,;37.89,-29.42,;37.89,-30.95,;39.22,-31.71,;40.56,-30.94,;40.55,-29.39,;39.21,-28.63,;41.89,-31.7,;43.21,-30.92,;44.55,-31.68,;44.56,-33.23,;43.23,-34,;41.89,-33.24,;45.88,-30.9,;47.2,-30.12,;26.19,-31,;24.85,-30.23,;23.52,-31,;23.52,-32.55,;24.87,-33.31,;26.19,-32.54,;22.19,-33.32,;20.86,-32.56,;19.53,-33.33,;19.53,-34.87,;20.88,-35.64,;22.2,-34.86,)| Show InChI InChI=1S/C31H36N8O2/c32-19-22-6-14-33-28(18-22)38-15-7-23(8-16-38)30(40)39-17-9-26(21-39)37-25-4-10-31(41,11-5-25)27-3-2-24(20-36-27)29-34-12-1-13-35-29/h1-3,6,12-14,18,20,23,25-26,37,41H,4-5,7-11,15-17,21H2/t25-,26-,31-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Antagonist activity at CCR2 receptor in human PBMC assessed as inhibition of MCP1-mediated leukocyte chemotaxis after 30 mins by microscopy |
ACS Med Chem Lett 2: 913-918 (2011)
Article DOI: 10.1021/ml200199c
BindingDB Entry DOI: 10.7270/Q29024TK |
More data for this
Ligand-Target Pair | |
C-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50382936
(CHEMBL2029571)Show SMILES O[C@]1(CC[C@@H](CC1)N[C@H]1CCN(C1)C(=O)C1CCN(CC1)c1cc(ccn1)C#N)c1ccc(cn1)-c1ncccn1 |r,wU:4.7,wD:1.0,8.8,(26.18,-29.46,;27.52,-30.23,;28.85,-30.99,;30.18,-30.23,;30.18,-28.69,;28.85,-27.91,;27.52,-28.69,;31.51,-27.93,;32.84,-28.7,;32.86,-30.23,;34.33,-30.69,;35.22,-29.43,;34.3,-28.2,;36.55,-28.66,;36.54,-27.12,;37.89,-29.42,;37.89,-30.95,;39.22,-31.71,;40.56,-30.94,;40.55,-29.39,;39.21,-28.63,;41.89,-31.7,;43.21,-30.92,;44.55,-31.68,;44.56,-33.23,;43.23,-34,;41.89,-33.24,;45.88,-30.9,;47.2,-30.12,;26.19,-31,;24.85,-30.23,;23.52,-31,;23.52,-32.55,;24.87,-33.31,;26.19,-32.54,;22.19,-33.32,;20.86,-32.56,;19.53,-33.33,;19.53,-34.87,;20.88,-35.64,;22.2,-34.86,)| Show InChI InChI=1S/C31H36N8O2/c32-19-22-6-14-33-28(18-22)38-15-7-23(8-16-38)30(40)39-17-9-26(21-39)37-25-4-10-31(41,11-5-25)27-3-2-24(20-36-27)29-34-12-1-13-35-29/h1-3,6,12-14,18,20,23,25-26,37,41H,4-5,7-11,15-17,21H2/t25-,26-,31-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Antagonist activity at CCR2 receptor in human whole blood assessed as inhibition of alexa-tagged MCP-induced effect 30 mins by flow cytometry |
ACS Med Chem Lett 2: 913-918 (2011)
Article DOI: 10.1021/ml200199c
BindingDB Entry DOI: 10.7270/Q29024TK |
More data for this
Ligand-Target Pair | |
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