BDBM50389108 CHEMBL2064632

SMILES: CN(C)C[C@@H](OC(=O)N1Cc2c(NC(=O)C3(CC3)C(F)(F)F)[nH]nc2C1(C)C)c1ccccc1

InChI Key: InChIKey=NORZHYUPBXCJOJ-MRXNPFEDSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50389108   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase PAK 4 (Homo sapiens (Human))	BDBM50389108 (CHEMBL2064632) Show SMILES CN(C)C[C@@H](OC(=O)N1Cc2c(NC(=O)C3(CC3)C(F)(F)F)[nH]nc2C1(C)C)c1ccccc1 |r| Show InChI InChI=1S/C23H28F3N5O3/c1-21(2)17-15(18(29-28-17)27-19(32)22(10-11-22)23(24,25)26)12-31(21)20(33)34-16(13-30(3)4)14-8-6-5-7-9-14/h5-9,16H,10-13H2,1-4H3,(H2,27,28,29,32)/t16-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	7	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of PAK4-mediated GEF-H1 phosphorylation at Ser810 by cell based assay				J Med Chem 55: 4728-39 (2012) Article DOI: 10.1021/jm300204j BindingDB Entry DOI: 10.7270/Q2BZ673W
					More data for this Ligand-Target Pair