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BDBM50392531 CHEMBL407632

SMILES: CCOc1cc(OC)ccc1C1=N[C@H]([C@H](N1C(=O)N1CCN(CCO)CC1)c1ccc(Br)cc1)c1ccc(Br)cc1

InChI Key: InChIKey=PVRYEWOXWGDQHA-URLMMPGGSA-N

Data: 4 IC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50392531
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50392531 (CHEMBL407632) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Comprehensive Cancer Center and Departments of Internal Medicine Curated by ChEMBL					Assay Description Binding affinity to MDM2 (unknown origin)				J Med Chem 58: 1038-52 (2015) Article DOI: 10.1021/jm501092z BindingDB Entry DOI: 10.7270/Q21G0NZ5
					More data for this Ligand-Target Pair				3D Structure (crystal)
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50392531 (CHEMBL407632) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Co., Ltd Curated by ChEMBL					Assay Description Inhibition of MDM2 binding to p53				Bioorg Med Chem Lett 22: 6338-42 (2012) Article DOI: 10.1016/j.bmcl.2012.08.086 BindingDB Entry DOI: 10.7270/Q2SX6F9R
Daiichi Sankyo Co., Ltd Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50392531 (CHEMBL407632) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi Curated by ChEMBL					Assay Description Antagonist activity at human GST-tagged MDM2 assessed as inhibition of binding to full length p53				Bioorg Med Chem Lett 23: 2480-5 (2013) Article DOI: 10.1016/j.bmcl.2013.03.034 BindingDB Entry DOI: 10.7270/Q2RN3970
Sanofi Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50392531 (CHEMBL407632) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh Curated by ChEMBL					Assay Description Binding affinity to MDM2 (unknown origin) expressed in Escherichia coli BL21(DE3) after 30 mins by fluorescence polarization assay in presence of P4 ...				Bioorg Med Chem 21: 3982-95 (2013) Article DOI: 10.1016/j.bmc.2012.06.020 BindingDB Entry DOI: 10.7270/Q2QV3NWD
University of Pittsburgh Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)