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SMILES: Cc1cccc(Nc2nc(nnc2-c2ccccc2)-c2ccccn2)n1

InChI Key: InChIKey=JQVHDQRNZLAXIV-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50393277   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Hypoxia-inducible factor 1-alpha (Homo sapiens (Human))	BDBM50393277 (CHEMBL2152032) Show SMILES Cc1cccc(Nc2nc(nnc2-c2ccccc2)-c2ccccn2)n1 Show InChI InChI=1S/C20H16N6/c1-14-8-7-12-17(22-14)23-20-18(15-9-3-2-4-10-15)25-26-19(24-20)16-11-5-6-13-21-16/h2-13H,1H3,(H,22,23,24,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	2.24E+4	n/a	n/a	n/a	n/a
The Broad Institute Probe Development Center Curated by ChEMBL					Assay Description Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubat...				Bioorg Med Chem Lett 22: 76-81 (2011) Article DOI: 10.1016/j.bmcl.2011.11.077 BindingDB Entry DOI: 10.7270/Q2XD12SN
					More data for this Ligand-Target Pair
Hypoxia-inducible factor 1-alpha (Homo sapiens (Human))	BDBM50393277 (CHEMBL2152032) Show SMILES Cc1cccc(Nc2nc(nnc2-c2ccccc2)-c2ccccn2)n1 Show InChI InChI=1S/C20H16N6/c1-14-8-7-12-17(22-14)23-20-18(15-9-3-2-4-10-15)25-26-19(24-20)16-11-5-6-13-21-16/h2-13H,1H3,(H,22,23,24,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	7.55E+3	n/a	n/a	n/a	n/a
The Broad Institute Probe Development Center Curated by ChEMBL					Assay Description Activation of human HIF1alpha expressed in human U2OS cells assessed as increase in VEGF expression by RT-PCR analysis				Bioorg Med Chem Lett 22: 76-81 (2011) Article DOI: 10.1016/j.bmcl.2011.11.077 BindingDB Entry DOI: 10.7270/Q2XD12SN
					More data for this Ligand-Target Pair
Hypoxia-inducible factor 1-alpha (Homo sapiens (Human))	BDBM50393277 (CHEMBL2152032) Show SMILES Cc1cccc(Nc2nc(nnc2-c2ccccc2)-c2ccccn2)n1 Show InChI InChI=1S/C20H16N6/c1-14-8-7-12-17(22-14)23-20-18(15-9-3-2-4-10-15)25-26-19(24-20)16-11-5-6-13-21-16/h2-13H,1H3,(H,22,23,24,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	5.41E+3	n/a	n/a	n/a	n/a
The Broad Institute Probe Development Center Curated by ChEMBL					Assay Description Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assay				Bioorg Med Chem Lett 22: 76-81 (2011) Article DOI: 10.1016/j.bmcl.2011.11.077 BindingDB Entry DOI: 10.7270/Q2XD12SN
					More data for this Ligand-Target Pair