BDBM50396915 CHEMBL2170781
SMILES: CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O
InChI Key: InChIKey=NCMQVOQOKBIHPA-MHRDGXECSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Ghrelin receptor (Homo sapiens (Human)) | BDBM50396915 (CHEMBL2170781) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 3.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Montpellier Curated by ChEMBL | Assay Description Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay | J Med Chem 62: 965-973 (2019) Article DOI: 10.1021/acs.jmedchem.8b01644 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ghrelin receptor (Homo sapiens (Human)) | BDBM50396915 (CHEMBL2170781) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 4.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£t Leipzig Curated by ChEMBL | Assay Description Displacement of [125I]-His-ghrelin from human ghrelin receptor expressed in COS7 cells incubated for 75 mins by scintillation counting based assay | J Med Chem 55: 7437-49 (2012) Article DOI: 10.1021/jm300414b BindingDB Entry DOI: 10.7270/Q26M37Z8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ghrelin receptor (Homo sapiens (Human)) | BDBM50396915 (CHEMBL2170781) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | n/a | n/a | n/a | n/a | 12 | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ghrelin receptor (Homo sapiens (Human)) | BDBM50396915 (CHEMBL2170781) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 3.40 | n/a | n/a | n/a | n/a |
Universit£t Leipzig Curated by ChEMBL | Assay Description Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay | J Med Chem 55: 7437-49 (2012) Article DOI: 10.1021/jm300414b BindingDB Entry DOI: 10.7270/Q26M37Z8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ghrelin receptor (Homo sapiens (Human)) | BDBM50396915 (CHEMBL2170781) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 5.5 | n/a | n/a | n/a | n/a |
Universit£ de Montpellier Curated by ChEMBL | Assay Description Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by... | J Med Chem 62: 965-973 (2019) Article DOI: 10.1021/acs.jmedchem.8b01644 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ghrelin receptor (Homo sapiens (Human)) | BDBM50396915 (CHEMBL2170781) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 3.80 | n/a | n/a | n/a | n/a |
Universit£t Leipzig Curated by ChEMBL | Assay Description Inverse agonist activity at FLAG-tagged human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover as... | J Med Chem 55: 7437-49 (2012) Article DOI: 10.1021/jm300414b BindingDB Entry DOI: 10.7270/Q26M37Z8 | |||||||||||
More data for this Ligand-Target Pair |