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BDBM50397775 CHEMBL2177188

SMILES: CC[C@H](N1[C@@H]([C@H](C[C@H](Cc2nnn[nH]2)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1)C(=O)OC(C)(C)C

InChI Key: InChIKey=PDGUCDUDEBRWJB-UWSZBUKDSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50397775   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
CREB-binding protein/p53


(Homo sapiens (Human))		BDBM50397775
PNG
(CHEMBL2177188)
Show SMILES CC[C@H](N1[C@@H]([C@H](C[C@H](Cc2nnn[nH]2)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1)C(=O)OC(C)(C)C |r|
Show InChI InChI=1S/C27H31Cl2N5O3/c1-5-22(26(36)37-27(2,3)4)34-24(16-9-11-19(28)12-10-16)21(17-7-6-8-20(29)13-17)14-18(25(34)35)15-23-30-32-33-31-23/h6-13,18,21-22,24H,5,14-15H2,1-4H3,(H,30,31,32,33)/t18-,21-,22+,24-/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

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DrugBank
antibodypedia
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PC cid
PC sid
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Similars
Article
PubMed
n/an/a 3.10E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Activity at p53 in human SJSA1 cells assessed as induction of p21 mRNA expression after 7 hrs by qRT-PCR analysis in presence of 10% human serum

J Med Chem 55: 4936-54 (2012)


Article DOI: 10.1021/jm300354j
BindingDB Entry DOI: 10.7270/Q2S75HGJ
More data for this
Ligand-Target Pair