Found 10 hits for monomerid = 50398609 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Proteasome component C5
(Homo sapiens (Human)) | BDBM50398609
(CHEMBL2141296 | IXAZOMIB CITRATE | Ixazomib | MLN2...)Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)c1cc(Cl)ccc1Cl)B(O)O Show InChI InChI=1S/C14H19BCl2N2O4/c1-8(2)5-12(15(22)23)19-13(20)7-18-14(21)10-6-9(16)3-4-11(10)17/h3-4,6,8,12,22-23H,5,7H2,1-2H3,(H,18,21)(H,19,20)/t12-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 31 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California-San Diego
Curated by ChEMBL
| Assay Description Reversible inhibition of human erythrocyte derived 20S proteasome subunit beta1 after 30 mins by fluorogenic assay |
J Med Chem 55: 10317-27 (2012)
Article DOI: 10.1021/jm300434z BindingDB Entry DOI: 10.7270/Q2668FBF |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Proteasome Macropain subunit
(Homo sapiens (Human)) | BDBM50398609
(CHEMBL2141296 | IXAZOMIB CITRATE | Ixazomib | MLN2...)Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)c1cc(Cl)ccc1Cl)B(O)O Show InChI InChI=1S/C14H19BCl2N2O4/c1-8(2)5-12(15(22)23)19-13(20)7-18-14(21)10-6-9(16)3-4-11(10)17/h3-4,6,8,12,22-23H,5,7H2,1-2H3,(H,18,21)(H,19,20)/t12-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 3.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California-San Diego
Curated by ChEMBL
| Assay Description Reversible inhibition of human erythrocyte derived 20S proteasome subunit beta2 after 30 mins by fluorogenic assay |
J Med Chem 55: 10317-27 (2012)
Article DOI: 10.1021/jm300434z BindingDB Entry DOI: 10.7270/Q2668FBF |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
20S proteasome chymotrypsin-like
(Homo sapiens (Human)) | BDBM50398609
(CHEMBL2141296 | IXAZOMIB CITRATE | Ixazomib | MLN2...)Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)c1cc(Cl)ccc1Cl)B(O)O Show InChI InChI=1S/C14H19BCl2N2O4/c1-8(2)5-12(15(22)23)19-13(20)7-18-14(21)10-6-9(16)3-4-11(10)17/h3-4,6,8,12,22-23H,5,7H2,1-2H3,(H,18,21)(H,19,20)/t12-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California-San Diego
Curated by ChEMBL
| Assay Description Reversible inhibition of human erythrocyte derived 20S proteasome subunit beta5 after 30 mins by fluorogenic assay |
J Med Chem 55: 10317-27 (2012)
Article DOI: 10.1021/jm300434z BindingDB Entry DOI: 10.7270/Q2668FBF |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Proteasome subunit beta type-1/beta type-5
(Homo sapiens (Human)) | BDBM50398609
(CHEMBL2141296 | IXAZOMIB CITRATE | Ixazomib | MLN2...)Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)c1cc(Cl)ccc1Cl)B(O)O Show InChI InChI=1S/C14H19BCl2N2O4/c1-8(2)5-12(15(22)23)19-13(20)7-18-14(21)10-6-9(16)3-4-11(10)17/h3-4,6,8,12,22-23H,5,7H2,1-2H3,(H,18,21)(H,19,20)/t12-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 7.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Nanjing Forestry University
Curated by ChEMBL
| Assay Description Inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate incubated for 10 mins followed by substra... |
Bioorg Med Chem 26: 3975-3981 (2018)
Article DOI: 10.1016/j.bmc.2018.06.020 BindingDB Entry DOI: 10.7270/Q2Q81GQG |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
ATP-dependent Clp protease proteolytic subunit
(Staphylococcus aureus (strain NCTC 8325)) | BDBM50398609
(CHEMBL2141296 | IXAZOMIB CITRATE | Ixazomib | MLN2...)Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)c1cc(Cl)ccc1Cl)B(O)O Show InChI InChI=1S/C14H19BCl2N2O4/c1-8(2)5-12(15(22)23)19-13(20)7-18-14(21)10-6-9(16)3-4-11(10)17/h3-4,6,8,12,22-23H,5,7H2,1-2H3,(H,18,21)(H,19,20)/t12-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | 5.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Sichuan University
Curated by ChEMBL
| Assay Description Inhibition of N-terminal His6-sumo-tagged full length Staphylococcus aureus ClpP expressed in Escherichia coli BL2 (DE3) pre-incubated for 10 mins be... |
J Med Chem 63: 3104-3119 (2020)
Article DOI: 10.1021/acs.jmedchem.9b01746 |
More data for this Ligand-Target Pair | |
Proteasome subunit beta type-1/beta type-5
(Homo sapiens (Human)) | BDBM50398609
(CHEMBL2141296 | IXAZOMIB CITRATE | Ixazomib | MLN2...)Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)c1cc(Cl)ccc1Cl)B(O)O Show InChI InChI=1S/C14H19BCl2N2O4/c1-8(2)5-12(15(22)23)19-13(20)7-18-14(21)10-6-9(16)3-4-11(10)17/h3-4,6,8,12,22-23H,5,7H2,1-2H3,(H,18,21)(H,19,20)/t12-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Hangzhou Xixi Hospital
Curated by ChEMBL
| Assay Description Inhibition of 20S proteasome beta 1c (unknown origin) after 1 hr by fluorescence based assay |
Eur J Med Chem 182: (2019)
Article DOI: 10.1016/j.ejmech.2019.111646 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
20S proteasome
(Homo sapiens (Human)) | BDBM50398609
(CHEMBL2141296 | IXAZOMIB CITRATE | Ixazomib | MLN2...)Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)c1cc(Cl)ccc1Cl)B(O)O Show InChI InChI=1S/C14H19BCl2N2O4/c1-8(2)5-12(15(22)23)19-13(20)7-18-14(21)10-6-9(16)3-4-11(10)17/h3-4,6,8,12,22-23H,5,7H2,1-2H3,(H,18,21)(H,19,20)/t12-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Hangzhou Xixi Hospital
Curated by ChEMBL
| Assay Description Inhibition of 20S proteasome beta 2c (unknown origin) after 1 hr by fluorescence based assay |
Eur J Med Chem 182: (2019)
Article DOI: 10.1016/j.ejmech.2019.111646 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Proteasome subunit beta type-1/beta type-5
(Homo sapiens (Human)) | BDBM50398609
(CHEMBL2141296 | IXAZOMIB CITRATE | Ixazomib | MLN2...)Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)c1cc(Cl)ccc1Cl)B(O)O Show InChI InChI=1S/C14H19BCl2N2O4/c1-8(2)5-12(15(22)23)19-13(20)7-18-14(21)10-6-9(16)3-4-11(10)17/h3-4,6,8,12,22-23H,5,7H2,1-2H3,(H,18,21)(H,19,20)/t12-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Hangzhou Xixi Hospital
Curated by ChEMBL
| Assay Description Inhibition of 20S proteasome beta 5c (unknown origin) after 1 hr by fluorescence based assay |
Eur J Med Chem 182: (2019)
Article DOI: 10.1016/j.ejmech.2019.111646 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
ATP-dependent Clp protease proteolytic subunit
(Staphylococcus aureus (strain NCTC 8325)) | BDBM50398609
(CHEMBL2141296 | IXAZOMIB CITRATE | Ixazomib | MLN2...)Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)c1cc(Cl)ccc1Cl)B(O)O Show InChI InChI=1S/C14H19BCl2N2O4/c1-8(2)5-12(15(22)23)19-13(20)7-18-14(21)10-6-9(16)3-4-11(10)17/h3-4,6,8,12,22-23H,5,7H2,1-2H3,(H,18,21)(H,19,20)/t12-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 3.60E+3 | n/a | n/a | n/a | n/a |
Sichuan University
Curated by ChEMBL
| Assay Description Inhibition of ClpP in methicillin-resistant Staphylococcus aureus ATCC 33591 assessed as reduction in bacteria-induced hemolysis of sheep erythrocyte... |
J Med Chem 63: 3104-3119 (2020)
Article DOI: 10.1021/acs.jmedchem.9b01746 |
More data for this Ligand-Target Pair | |
20S proteasome
(Homo sapiens (Human)) | BDBM50398609
(CHEMBL2141296 | IXAZOMIB CITRATE | Ixazomib | MLN2...)Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)c1cc(Cl)ccc1Cl)B(O)O Show InChI InChI=1S/C14H19BCl2N2O4/c1-8(2)5-12(15(22)23)19-13(20)7-18-14(21)10-6-9(16)3-4-11(10)17/h3-4,6,8,12,22-23H,5,7H2,1-2H3,(H,18,21)(H,19,20)/t12-/m0/s1 | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Auckland
Curated by ChEMBL
| Assay Description Inhibition of human 20S proteasome using Suc-LLVY-AMC as substrate measured every 5 mins for 120 mins by fluorescence based assay |
J Med Chem 63: 334-348 (2020)
Article DOI: 10.1021/acs.jmedchem.9b01694 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |