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SMILES: FC(F)(F)Oc1ccc(Nc2c(Nc3ccnc(Nc4ccc(cc4)-c4ccccc4)n3)c(=O)c2=O)cc1

InChI Key: InChIKey=SSWUPFAVGNSTID-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50402031   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))		BDBM50402031
PNG
(CHEMBL2205453)
Show SMILES FC(F)(F)Oc1ccc(Nc2c(Nc3ccnc(Nc4ccc(cc4)-c4ccccc4)n3)c(=O)c2=O)cc1
Show InChI InChI=1S/C27H18F3N5O3/c28-27(29,30)38-20-12-10-18(11-13-20)32-22-23(25(37)24(22)36)34-21-14-15-31-26(35-21)33-19-8-6-17(7-9-19)16-4-2-1-3-5-16/h1-15,32H,(H2,31,33,34,35)
PDB
MMDB

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PC cid
PC sid
UniChem
Article
PubMed
 1.76E+4n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of PLK1 in human MIAPaCa2 cells after 48 hrs by MTT assay

Bioorg Med Chem Lett 22: 7615-22 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.009
BindingDB Entry DOI: 10.7270/Q2XK8GQ3
More data for this
Ligand-Target Pair