BDBM50405028 CHEMBL4166386

SMILES: COc1ccc(NC2(C(=O)N(C(=O)C2=Cc2ccccc2)C(C)(C)C)c2ccccc2)cc1

InChI Key: InChIKey=RDQUKXHNHWGTLC-UHFFFAOYSA-N

Data: 2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50405028   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histamine H3 receptor (Homo sapiens (Human))	BDBM50405028 (CHEMBL4166386) Show SMILES COc1ccc(NC2(C(=O)N(C(=O)C2=Cc2ccccc2)C(C)(C)C)c2ccccc2)cc1 Show InChI InChI=1S/C23H24ClN3O7/c24-16-3-1-15(2-4-16)12-25-7-9-26(10-8-25)13-17(28)14-33-18-5-6-19-20(11-18)34-23(30)21(22(19)29)27(31)32/h1-6,11,17,28-29H,7-10,12-14H2	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	3	n/a	n/a	n/a	n/a
CSIR-Central Drug Research Institute Curated by ChEMBL					Assay Description Agonist activity at human H3R expressed in HEK293 cells harboring glosensor-22F cAMP plasmid DNA assessed as inhibition of forskolin-stimulated cAMP ...				Eur J Med Chem 152: 148-159 (2018) Article DOI: 10.1016/j.ejmech.2018.04.020 BindingDB Entry DOI: 10.7270/Q2QC063R
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50405028 (CHEMBL4166386) Show SMILES COc1ccc(NC2(C(=O)N(C(=O)C2=Cc2ccccc2)C(C)(C)C)c2ccccc2)cc1 Show InChI InChI=1S/C23H24ClN3O7/c24-16-3-1-15(2-4-16)12-25-7-9-26(10-8-25)13-17(28)14-33-18-5-6-19-20(11-18)34-23(30)21(22(19)29)27(31)32/h1-6,11,17,28-29H,7-10,12-14H2	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	23	n/a	n/a	n/a	n/a
CSIR-Central Drug Research Institute Curated by ChEMBL					Assay Description Agonist activity at human H3R expressed in HEK293 cells harboring glosensor-22F cAMP plasmid DNA assessed as inhibition of forskolin-stimulated cAMP ...				Eur J Med Chem 152: 148-159 (2018) Article DOI: 10.1016/j.ejmech.2018.04.020 BindingDB Entry DOI: 10.7270/Q2QC063R
					More data for this Ligand-Target Pair