BDBM50408426 CHEMBL2092833

SMILES: Cc1cn([C@@H]2C[C@@H](F)[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O2)c(=O)[nH]c1=O

InChI Key: InChIKey=UNKRRBWXJZNMAN-CSMHCCOUSA-N

Data: 9 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50408426   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Human immunodeficiency virus type 1 reverse transcriptase (Human immunodeficiency virus 1)	BDBM50408426 (CHEMBL2092833) Show SMILES Cc1cn([C@@H]2C[C@@H](F)[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O2)c(=O)[nH]c1=O |r| Show InChI InChI=1S/C10H16FN2O13P3/c1-5-3-13(10(15)12-9(5)14)8-2-6(11)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18/h3,6-8H,2,4H2,1H3,(H,19,20)(H,21,22)(H,12,14,15)(H2,16,17,18)/t6-,7+,8+/m1/s1	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Max-Delbr�ck-Centrum f�r Molekulare Medizin Curated by ChEMBL					Assay Description Compound was evaluated for 50% inhibition of HIV-RT (HIV reverse transcriptase)				J Med Chem 41: 2040-6 (1998) Article DOI: 10.1021/jm9704210 BindingDB Entry DOI: 10.7270/Q2FT8MQT
					More data for this Ligand-Target Pair
DNA polymerase beta (Homo sapiens (Human))	BDBM50408426 (CHEMBL2092833) Show SMILES Cc1cn([C@@H]2C[C@@H](F)[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O2)c(=O)[nH]c1=O |r| Show InChI InChI=1S/C10H16FN2O13P3/c1-5-3-13(10(15)12-9(5)14)8-2-6(11)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18/h3,6-8H,2,4H2,1H3,(H,19,20)(H,21,22)(H,12,14,15)(H2,16,17,18)/t6-,7+,8+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Max-Delbr�ck-Centrum f�r Molekulare Medizin Curated by ChEMBL					Assay Description Compound was evaluated for the inhibition of cellular DNA polymerase (beta)				J Med Chem 41: 2040-6 (1998) Article DOI: 10.1021/jm9704210 BindingDB Entry DOI: 10.7270/Q2FT8MQT
					More data for this Ligand-Target Pair
DNA polymerase (alpha/delta/epsilon) (Homo sapiens (Human))	BDBM50408426 (CHEMBL2092833) Show SMILES Cc1cn([C@@H]2C[C@@H](F)[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O2)c(=O)[nH]c1=O |r| Show InChI InChI=1S/C10H16FN2O13P3/c1-5-3-13(10(15)12-9(5)14)8-2-6(11)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18/h3,6-8H,2,4H2,1H3,(H,19,20)(H,21,22)(H,12,14,15)(H2,16,17,18)/t6-,7+,8+/m1/s1	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Max-Delbr�ck-Centrum f�r Molekulare Medizin Curated by ChEMBL					Assay Description Compound was evaluated for the inhibition of cellular DNA polymerase (alpha)				J Med Chem 41: 2040-6 (1998) Article DOI: 10.1021/jm9704210 BindingDB Entry DOI: 10.7270/Q2FT8MQT
					More data for this Ligand-Target Pair
DNA polymerase gamma subunit 1 (Homo sapiens (Human))	BDBM50408426 (CHEMBL2092833) Show SMILES Cc1cn([C@@H]2C[C@@H](F)[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O2)c(=O)[nH]c1=O |r| Show InChI InChI=1S/C10H16FN2O13P3/c1-5-3-13(10(15)12-9(5)14)8-2-6(11)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18/h3,6-8H,2,4H2,1H3,(H,19,20)(H,21,22)(H,12,14,15)(H2,16,17,18)/t6-,7+,8+/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Max-Delbr�ck-Centrum f�r Molekulare Medizin Curated by ChEMBL					Assay Description Compound was evaluated for the inhibition of cellular DNA polymerase (gamma)				J Med Chem 41: 2040-6 (1998) Article DOI: 10.1021/jm9704210 BindingDB Entry DOI: 10.7270/Q2FT8MQT
					More data for this Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase (Human immunodeficiency virus 1)	BDBM50408426 (CHEMBL2092833) Show SMILES Cc1cn([C@@H]2C[C@@H](F)[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O2)c(=O)[nH]c1=O |r| Show InChI InChI=1S/C10H16FN2O13P3/c1-5-3-13(10(15)12-9(5)14)8-2-6(11)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18/h3,6-8H,2,4H2,1H3,(H,19,20)(H,21,22)(H,12,14,15)(H2,16,17,18)/t6-,7+,8+/m1/s1	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Max-Delbr�ck-Centrum f�r Molekulare Medizin Curated by ChEMBL					Assay Description Compound was evaluated for 50% inhibition of HIV-RT (HIV reverse transcriptase)				J Med Chem 41: 2040-6 (1998) Article DOI: 10.1021/jm9704210 BindingDB Entry DOI: 10.7270/Q2FT8MQT
					More data for this Ligand-Target Pair
DNA polymerase beta (Homo sapiens (Human))	BDBM50408426 (CHEMBL2092833) Show SMILES Cc1cn([C@@H]2C[C@@H](F)[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O2)c(=O)[nH]c1=O |r| Show InChI InChI=1S/C10H16FN2O13P3/c1-5-3-13(10(15)12-9(5)14)8-2-6(11)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18/h3,6-8H,2,4H2,1H3,(H,19,20)(H,21,22)(H,12,14,15)(H2,16,17,18)/t6-,7+,8+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Max-Delbr�ck-Centrum f�r Molekulare Medizin Curated by ChEMBL					Assay Description Compound was evaluated for the inhibition of cellular DNA polymerase (beta)				J Med Chem 41: 2040-6 (1998) Article DOI: 10.1021/jm9704210 BindingDB Entry DOI: 10.7270/Q2FT8MQT
					More data for this Ligand-Target Pair
DNA polymerase gamma subunit 1 (Homo sapiens (Human))	BDBM50408426 (CHEMBL2092833) Show SMILES Cc1cn([C@@H]2C[C@@H](F)[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O2)c(=O)[nH]c1=O |r| Show InChI InChI=1S/C10H16FN2O13P3/c1-5-3-13(10(15)12-9(5)14)8-2-6(11)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18/h3,6-8H,2,4H2,1H3,(H,19,20)(H,21,22)(H,12,14,15)(H2,16,17,18)/t6-,7+,8+/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Max-Delbr�ck-Centrum f�r Molekulare Medizin Curated by ChEMBL					Assay Description Compound was evaluated for the inhibition of cellular DNA polymerase (gamma)				J Med Chem 41: 2040-6 (1998) Article DOI: 10.1021/jm9704210 BindingDB Entry DOI: 10.7270/Q2FT8MQT
					More data for this Ligand-Target Pair
DNA polymerase (alpha/delta/epsilon) (Homo sapiens (Human))	BDBM50408426 (CHEMBL2092833) Show SMILES Cc1cn([C@@H]2C[C@@H](F)[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O2)c(=O)[nH]c1=O |r| Show InChI InChI=1S/C10H16FN2O13P3/c1-5-3-13(10(15)12-9(5)14)8-2-6(11)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18/h3,6-8H,2,4H2,1H3,(H,19,20)(H,21,22)(H,12,14,15)(H2,16,17,18)/t6-,7+,8+/m1/s1	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Max-Delbr�ck-Centrum f�r Molekulare Medizin Curated by ChEMBL					Assay Description Compound was evaluated for the inhibition of cellular DNA polymerase (alpha)				J Med Chem 41: 2040-6 (1998) Article DOI: 10.1021/jm9704210 BindingDB Entry DOI: 10.7270/Q2FT8MQT
					More data for this Ligand-Target Pair
DNA polymerase (alpha/delta/epsilon) (Homo sapiens (Human))	BDBM50408426 (CHEMBL2092833) Show SMILES Cc1cn([C@@H]2C[C@@H](F)[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O2)c(=O)[nH]c1=O |r| Show InChI InChI=1S/C10H16FN2O13P3/c1-5-3-13(10(15)12-9(5)14)8-2-6(11)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18/h3,6-8H,2,4H2,1H3,(H,19,20)(H,21,22)(H,12,14,15)(H2,16,17,18)/t6-,7+,8+/m1/s1	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	170	n/a	n/a	n/a	n/a	n/a	n/a
Max-Delbr�ck-Centrum f�r Molekulare Medizin Curated by ChEMBL					Assay Description Compound was evaluated for 50% inhibition of DHBV DNA polymerase (duck hepatitis B virus)				J Med Chem 41: 2040-6 (1998) Article DOI: 10.1021/jm9704210 BindingDB Entry DOI: 10.7270/Q2FT8MQT
					More data for this Ligand-Target Pair