Found 5 hits for monomerid = 50414625 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Procathepsin L
(Homo sapiens (Human)) | BDBM50414625
(CHEMBL559248)Show SMILES Cn1nccc1-c1cccc(CC(NC(=O)c2ccccc2)C(=O)NCC#N)c1 Show InChI InChI=1S/C22H21N5O2/c1-27-20(10-12-25-27)18-9-5-6-16(14-18)15-19(22(29)24-13-11-23)26-21(28)17-7-3-2-4-8-17/h2-10,12,14,19H,13,15H2,1H3,(H,24,29)(H,26,28) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.16E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of cathepsin L assessed as inhibition of fluorogenic substrate cleavage |
Bioorg Med Chem Lett 19: 4622-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.090 BindingDB Entry DOI: 10.7270/Q2N017S3 |
More data for this Ligand-Target Pair | |
Cathepsin L2
(Homo sapiens (Human)) | BDBM50414625
(CHEMBL559248)Show SMILES Cn1nccc1-c1cccc(CC(NC(=O)c2ccccc2)C(=O)NCC#N)c1 Show InChI InChI=1S/C22H21N5O2/c1-27-20(10-12-25-27)18-9-5-6-16(14-18)15-19(22(29)24-13-11-23)26-21(28)17-7-3-2-4-8-17/h2-10,12,14,19H,13,15H2,1H3,(H,24,29)(H,26,28) | PDB MMDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.16E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of cathepsin L2 assessed as inhibition of fluorogenic substrate cleavage |
Bioorg Med Chem Lett 19: 4622-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.090 BindingDB Entry DOI: 10.7270/Q2N017S3 |
More data for this Ligand-Target Pair | |
Cathepsin S
(Homo sapiens (Human)) | BDBM50414625
(CHEMBL559248)Show SMILES Cn1nccc1-c1cccc(CC(NC(=O)c2ccccc2)C(=O)NCC#N)c1 Show InChI InChI=1S/C22H21N5O2/c1-27-20(10-12-25-27)18-9-5-6-16(14-18)15-19(22(29)24-13-11-23)26-21(28)17-7-3-2-4-8-17/h2-10,12,14,19H,13,15H2,1H3,(H,24,29)(H,26,28) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 316 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of cathepsin S assessed as inhibition of fluorogenic substrate cleavage |
Bioorg Med Chem Lett 19: 4622-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.090 BindingDB Entry DOI: 10.7270/Q2N017S3 |
More data for this Ligand-Target Pair | |
Cathepsin K
(Homo sapiens (Human)) | BDBM50414625
(CHEMBL559248)Show SMILES Cn1nccc1-c1cccc(CC(NC(=O)c2ccccc2)C(=O)NCC#N)c1 Show InChI InChI=1S/C22H21N5O2/c1-27-20(10-12-25-27)18-9-5-6-16(14-18)15-19(22(29)24-13-11-23)26-21(28)17-7-3-2-4-8-17/h2-10,12,14,19H,13,15H2,1H3,(H,24,29)(H,26,28) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of cathepsin K assessed as inhibition of fluorogenic substrate cleavage |
Bioorg Med Chem Lett 19: 4622-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.090 BindingDB Entry DOI: 10.7270/Q2N017S3 |
More data for this Ligand-Target Pair | |
Cathepsin B
(Homo sapiens (Human)) | BDBM50414625
(CHEMBL559248)Show SMILES Cn1nccc1-c1cccc(CC(NC(=O)c2ccccc2)C(=O)NCC#N)c1 Show InChI InChI=1S/C22H21N5O2/c1-27-20(10-12-25-27)18-9-5-6-16(14-18)15-19(22(29)24-13-11-23)26-21(28)17-7-3-2-4-8-17/h2-10,12,14,19H,13,15H2,1H3,(H,24,29)(H,26,28) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7.94E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of human liver cathepsin B assessed as inhibition of fluorogenic substrate cleavage |
Bioorg Med Chem Lett 19: 4622-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.090 BindingDB Entry DOI: 10.7270/Q2N017S3 |
More data for this Ligand-Target Pair | |