new BindingDB logo
myBDB logout

BDBM50420088 CHEMBL2047523

SMILES: FC(F)(F)c1cccc(c1)C(=O)Nc1cnc(Cl)nc1

InChI Key: InChIKey=VDYCLHFQPCILDP-UHFFFAOYSA-N

Data: 1 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50420088   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Voltage-gated potassium channel beta subunit Mink/subunit Kv7.1


(Homo sapiens (Human))
BDBM50420088
PNG
(CHEMBL2047523)
Show SMILES FC(F)(F)c1cccc(c1)C(=O)Nc1cnc(Cl)nc1
Show InChI InChI=1S/C12H7ClF3N3O/c13-11-17-5-9(6-18-11)19-10(20)7-2-1-3-8(4-7)12(14,15)16/h1-6H,(H,19,20)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.50E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonist activity at KCNQ1/MINK expressed in CHO cells assessed as inhibition of KCl-induced 86Rb+ efflux incubated for 10 mins prior to KCl-induct...


ACS Med Chem Lett 2: 481-484 (2011)


Article DOI: 10.1021/ml200053x
BindingDB Entry DOI: 10.7270/Q2R49RVJ
More data for this
Ligand-Target Pair
Voltage-gated potassium channel subunit Kv7.2/Kv7.3


(Homo sapiens (Human))
BDBM50420088
PNG
(CHEMBL2047523)
Show SMILES FC(F)(F)c1cccc(c1)C(=O)Nc1cnc(Cl)nc1
Show InChI InChI=1S/C12H7ClF3N3O/c13-11-17-5-9(6-18-11)19-10(20)7-2-1-3-8(4-7)12(14,15)16/h1-6H,(H,19,20)
PDB

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 4.30E+3n/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Agonist activity at KCNQ2/KCNQ3 expressed in CHO cells assessed as increase in KCl-induced 86Rb+ efflux incubated for 10 mins prior to KCl-induction ...


ACS Med Chem Lett 2: 481-484 (2011)


Article DOI: 10.1021/ml200053x
BindingDB Entry DOI: 10.7270/Q2R49RVJ
More data for this
Ligand-Target Pair