BindingDB PrimarySearch

BDBM50431029 CHEMBL574646

SMILES: O=C1\C(CNC\C1=C/c1ccccn1)=C\c1ccccn1

InChI Key: InChIKey=GXFKPANENAOEOK-UTLPMFLDSA-N

Data: 13 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50431029
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
MAP kinase-activated protein kinase 2 (Homo sapiens (Human))	BDBM50431029 (CHEMBL574646) Show SMILES O=C1\C(CNC\C1=C/c1ccccn1)=C\c1ccccn1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Emory University Curated by ChEMBL					Assay Description Inhibition of recombinant MAPKAPK2 (unknown origin) by FRET-based Z'-LYTE assay				J Med Chem 56: 3456-66 (2013) Article DOI: 10.1021/jm4002692 BindingDB Entry DOI: 10.7270/Q2SB473Z
Emory University Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50431029 (CHEMBL574646) Show SMILES O=C1\C(CNC\C1=C/c1ccccn1)=C\c1ccccn1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Emory University Curated by ChEMBL					Assay Description Inhibition of recombinant MAPK14 (unknown origin) by FRET-based Z'-LYTE assay				J Med Chem 56: 3456-66 (2013) Article DOI: 10.1021/jm4002692 BindingDB Entry DOI: 10.7270/Q2SB473Z
Emory University Curated by ChEMBL					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50431029 (CHEMBL574646) Show SMILES O=C1\C(CNC\C1=C/c1ccccn1)=C\c1ccccn1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	660	n/a	n/a	n/a	n/a	n/a	n/a
Emory University Curated by ChEMBL					Assay Description Inhibition of recombinant KDR (unknown origin) by FRET-based Z'-LYTE assay				J Med Chem 56: 3456-66 (2013) Article DOI: 10.1021/jm4002692 BindingDB Entry DOI: 10.7270/Q2SB473Z
Emory University Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Nek1 (Homo sapiens (Human))	BDBM50431029 (CHEMBL574646) Show SMILES O=C1\C(CNC\C1=C/c1ccccn1)=C\c1ccccn1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
Emory University Curated by ChEMBL					Assay Description Inhibition of recombinant NEK1 (unknown origin) by FRET-based Z'-LYTE assay				J Med Chem 56: 3456-66 (2013) Article DOI: 10.1021/jm4002692 BindingDB Entry DOI: 10.7270/Q2SB473Z
Emory University Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM50431029 (CHEMBL574646) Show SMILES O=C1\C(CNC\C1=C/c1ccccn1)=C\c1ccccn1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Emory University Curated by ChEMBL					Assay Description Inhibition of recombinant ERK2 (unknown origin) by FRET-based Z'-LYTE assay				J Med Chem 56: 3456-66 (2013) Article DOI: 10.1021/jm4002692 BindingDB Entry DOI: 10.7270/Q2SB473Z
Emory University Curated by ChEMBL					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1 (Homo sapiens (Human))	BDBM50431029 (CHEMBL574646) Show SMILES O=C1\C(CNC\C1=C/c1ccccn1)=C\c1ccccn1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Emory University Curated by ChEMBL					Assay Description Inhibition of recombinant MEK1 (unknown origin) by cascade reaction assay				J Med Chem 56: 3456-66 (2013) Article DOI: 10.1021/jm4002692 BindingDB Entry DOI: 10.7270/Q2SB473Z
Emory University Curated by ChEMBL					More data for this Ligand-Target Pair
Peroxiredoxin-1 (Homo sapiens)	BDBM50431029 (CHEMBL574646) Show SMILES O=C1\C(CNC\C1=C/c1ccccn1)=C\c1ccccn1 Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	950	n/a	n/a	n/a	n/a	n/a	n/a
Shandong University Curated by ChEMBL					Assay Description Inhibition of PRDX1 in human PMA-differentiated LPS-stimulated THP1 cells assessed as reduction in NLRP3 inflammasome activation preincubated for 1 h...				Eur J Med Chem 185: (2020) Article DOI: 10.1016/j.ejmech.2019.111822
Shandong University Curated by ChEMBL					More data for this Ligand-Target Pair
5'-AMP-activated protein kinase Complex 1 (Homo sapiens (Human))	BDBM50431029 (CHEMBL574646) Show SMILES O=C1\C(CNC\C1=C/c1ccccn1)=C\c1ccccn1 Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Emory University Curated by ChEMBL					Assay Description Inhibition of recombinant AMPK A1/B1/G1 (unknown origin) by FRET-based Z'-LYTE assay				J Med Chem 56: 3456-66 (2013) Article DOI: 10.1021/jm4002692 BindingDB Entry DOI: 10.7270/Q2SB473Z
Emory University Curated by ChEMBL					More data for this Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K) (Homo sapiens (Human))	BDBM50431029 (CHEMBL574646) Show SMILES O=C1\C(CNC\C1=C/c1ccccn1)=C\c1ccccn1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Emory University Curated by ChEMBL					Assay Description Inhibition of recombinant RPS6K1 (unknown origin) by FRET-based Z'-LYTE assay				J Med Chem 56: 3456-66 (2013) Article DOI: 10.1021/jm4002692 BindingDB Entry DOI: 10.7270/Q2SB473Z
Emory University Curated by ChEMBL					More data for this Ligand-Target Pair
Inhibitor of nuclear factor kappa-B kinase subunit beta (Homo sapiens (Human))	BDBM50431029 (CHEMBL574646) Show SMILES O=C1\C(CNC\C1=C/c1ccccn1)=C\c1ccccn1 Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Emory University Curated by ChEMBL					Assay Description Inhibition of recombinant IKBKB (unknown origin) by FRET-based Z'-LYTE assay				J Med Chem 56: 3456-66 (2013) Article DOI: 10.1021/jm4002692 BindingDB Entry DOI: 10.7270/Q2SB473Z
Emory University Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase AKT2 (Homo sapiens (Human))	BDBM50431029 (CHEMBL574646) Show SMILES O=C1\C(CNC\C1=C/c1ccccn1)=C\c1ccccn1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Emory University Curated by ChEMBL					Assay Description Inhibition of recombinant AKT2 (unknown origin) by FRET-based Z'-LYTE assay				J Med Chem 56: 3456-66 (2013) Article DOI: 10.1021/jm4002692 BindingDB Entry DOI: 10.7270/Q2SB473Z
Emory University Curated by ChEMBL					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50431029 (CHEMBL574646) Show SMILES O=C1\C(CNC\C1=C/c1ccccn1)=C\c1ccccn1 Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Emory University Curated by ChEMBL					Assay Description Inhibition of recombinant AKT1 (unknown origin) by FRET-based Z'-LYTE assay				J Med Chem 56: 3456-66 (2013) Article DOI: 10.1021/jm4002692 BindingDB Entry DOI: 10.7270/Q2SB473Z
Emory University Curated by ChEMBL					More data for this Ligand-Target Pair
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50431029 (CHEMBL574646) Show SMILES O=C1\C(CNC\C1=C/c1ccccn1)=C\c1ccccn1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Emory University Curated by ChEMBL					Assay Description Inhibition of recombinant RAF1 (unknown origin) by cascade reaction assay				J Med Chem 56: 3456-66 (2013) Article DOI: 10.1021/jm4002692 BindingDB Entry DOI: 10.7270/Q2SB473Z
Emory University Curated by ChEMBL					More data for this Ligand-Target Pair