BDBM50437867 CHEMBL2407904

SMILES: COc1cc(\C=C2/C(=O)N(C)c3ccc(Br)cc23)cc(Cl)c1O

InChI Key: InChIKey=GKBCILCXUSENIW-XGICHPGQSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50437867   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase PLK4 (Homo sapiens (Human))	BDBM50437867 (CHEMBL2407904) Show SMILES COc1cc(\C=C2/C(=O)N(C)c3ccc(Br)cc23)cc(Cl)c1O Show InChI InChI=1S/C17H13BrClNO3/c1-20-14-4-3-10(18)8-11(14)12(17(20)22)5-9-6-13(19)16(21)15(7-9)23-2/h3-8,21H,1-2H3/b12-5-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
EntreMed Inc. Curated by ChEMBL					Assay Description Inhibition of N-terminal GST-tagged human PLK4 (1 to 391 amino acids) expressed in Escherichia coli using TMB as substrate after 30 mins by indirect ...				J Med Chem 56: 6069-87 (2013) Article DOI: 10.1021/jm400380m BindingDB Entry DOI: 10.7270/Q2HM59V9
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PLK1 (Homo sapiens (Human))	BDBM50437867 (CHEMBL2407904) Show SMILES COc1cc(\C=C2/C(=O)N(C)c3ccc(Br)cc23)cc(Cl)c1O Show InChI InChI=1S/C17H13BrClNO3/c1-20-14-4-3-10(18)8-11(14)12(17(20)22)5-9-6-13(19)16(21)15(7-9)23-2/h3-8,21H,1-2H3/b12-5-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
EntreMed Inc. Curated by ChEMBL					Assay Description Inhibition of PLK1 (unknown origin) by FRET-based homogeneous assay				J Med Chem 56: 6069-87 (2013) Article DOI: 10.1021/jm400380m BindingDB Entry DOI: 10.7270/Q2HM59V9
					More data for this Ligand-Target Pair