Found 4 hits for monomerid = 50439471 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Tissue-type plasminogen activator
(Homo sapiens (Human)) | BDBM50439471
(CHEMBL2417909)Show SMILES COc1ccc(-c2ccc(cc2C(O)=O)C(=O)NCC(C)(C)C)c(n1)C(=O)Nc1ccc2nc(N)[nH]c2c1 Show InChI InChI=1S/C27H28N6O5/c1-27(2,3)13-29-23(34)14-5-7-16(18(11-14)25(36)37)17-8-10-21(38-4)33-22(17)24(35)30-15-6-9-19-20(12-15)32-26(28)31-19/h5-12H,13H2,1-4H3,(H,29,34)(H,30,35)(H,36,37)(H3,28,31,32) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research& Development
Curated by ChEMBL
| Assay Description
Inhibition of human tissue plasminogen activator using spectrozyme tissue plasminogen activator as substrate after 3 mins |
Bioorg Med Chem Lett 23: 5239-43 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.028
BindingDB Entry DOI: 10.7270/Q2CC123C |
More data for this
Ligand-Target Pair | |
Coagulation factor VII
(Homo sapiens (Human)) | BDBM50439471
(CHEMBL2417909)Show SMILES COc1ccc(-c2ccc(cc2C(O)=O)C(=O)NCC(C)(C)C)c(n1)C(=O)Nc1ccc2nc(N)[nH]c2c1 Show InChI InChI=1S/C27H28N6O5/c1-27(2,3)13-29-23(34)14-5-7-16(18(11-14)25(36)37)17-8-10-21(38-4)33-22(17)24(35)30-15-6-9-19-20(12-15)32-26(28)31-19/h5-12H,13H2,1-4H3,(H,29,34)(H,30,35)(H,36,37)(H3,28,31,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 164 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research& Development
Curated by ChEMBL
| Assay Description
Inhibition of human F7a using D-Ile-Pro-Arg-AFC as substrate after 3 mins |
Bioorg Med Chem Lett 23: 5239-43 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.028
BindingDB Entry DOI: 10.7270/Q2CC123C |
More data for this
Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50439471
(CHEMBL2417909)Show SMILES COc1ccc(-c2ccc(cc2C(O)=O)C(=O)NCC(C)(C)C)c(n1)C(=O)Nc1ccc2nc(N)[nH]c2c1 Show InChI InChI=1S/C27H28N6O5/c1-27(2,3)13-29-23(34)14-5-7-16(18(11-14)25(36)37)17-8-10-21(38-4)33-22(17)24(35)30-15-6-9-19-20(12-15)32-26(28)31-19/h5-12H,13H2,1-4H3,(H,29,34)(H,30,35)(H,36,37)(H3,28,31,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research& Development
Curated by ChEMBL
| Assay Description
Inhibition of human F10a using S-2222 as substrate after 3 mins |
Bioorg Med Chem Lett 23: 5239-43 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.028
BindingDB Entry DOI: 10.7270/Q2CC123C |
More data for this
Ligand-Target Pair | |
Coagulation factor XI
(Homo sapiens (Human)) | BDBM50439471
(CHEMBL2417909)Show SMILES COc1ccc(-c2ccc(cc2C(O)=O)C(=O)NCC(C)(C)C)c(n1)C(=O)Nc1ccc2nc(N)[nH]c2c1 Show InChI InChI=1S/C27H28N6O5/c1-27(2,3)13-29-23(34)14-5-7-16(18(11-14)25(36)37)17-8-10-21(38-4)33-22(17)24(35)30-15-6-9-19-20(12-15)32-26(28)31-19/h5-12H,13H2,1-4H3,(H,29,34)(H,30,35)(H,36,37)(H3,28,31,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.08E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research& Development
Curated by ChEMBL
| Assay Description
Inhibition of human F11a using S-2366 as substrate after 3 mins |
Bioorg Med Chem Lett 23: 5239-43 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.028
BindingDB Entry DOI: 10.7270/Q2CC123C |
More data for this
Ligand-Target Pair | |
Search and Browse
