BDBM50440089 CHEMBL2426089

SMILES: OC(=O)CCC(=O)N1N=C(CC1c1ccc(cc1)C(F)(F)F)c1c(-c2ccccc2)c2cc(Cl)ccc2[nH]c1=O

InChI Key: InChIKey=JMLZANPUPVANFX-UHFFFAOYSA-N

Data: 4 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50440089   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glutamate receptor ionotropic, NMDA 2D (Rattus norvegicus (Rat))	BDBM50440089 (CHEMBL2426089) Show SMILES OC(=O)CCC(=O)N1N=C(CC1c1ccc(cc1)C(F)(F)F)c1c(-c2ccccc2)c2cc(Cl)ccc2[nH]c1=O |c:8| Show InChI InChI=1S/C29H21ClF3N3O4/c30-19-10-11-21-20(14-19)26(17-4-2-1-3-5-17)27(28(40)34-21)22-15-23(36(35-22)24(37)12-13-25(38)39)16-6-8-18(9-7-16)29(31,32)33/h1-11,14,23H,12-13,15H2,(H,34,40)(H,38,39)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Emory University Curated by ChEMBL					Assay Description Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp method				J Med Chem 56: 6434-56 (2013) Article DOI: 10.1021/jm400652r BindingDB Entry DOI: 10.7270/Q26H4JTJ
					More data for this Ligand-Target Pair
NMDA receptor subunit 2C (GluN2C) (Rattus norvegicus (Rat))	BDBM50440089 (CHEMBL2426089) Show SMILES OC(=O)CCC(=O)N1N=C(CC1c1ccc(cc1)C(F)(F)F)c1c(-c2ccccc2)c2cc(Cl)ccc2[nH]c1=O |c:8| Show InChI InChI=1S/C29H21ClF3N3O4/c30-19-10-11-21-20(14-19)26(17-4-2-1-3-5-17)27(28(40)34-21)22-15-23(36(35-22)24(37)12-13-25(38)39)16-6-8-18(9-7-16)29(31,32)33/h1-11,14,23H,12-13,15H2,(H,34,40)(H,38,39)	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Emory University Curated by ChEMBL					Assay Description Negative allosteric modulation of recombinant rat GluN2C receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp method				J Med Chem 56: 6434-56 (2013) Article DOI: 10.1021/jm400652r BindingDB Entry DOI: 10.7270/Q26H4JTJ
					More data for this Ligand-Target Pair
DNA repair protein RAD51 homolog 1 (Homo sapiens (Human))	BDBM50440089 (CHEMBL2426089) Show SMILES OC(=O)CCC(=O)N1N=C(CC1c1ccc(cc1)C(F)(F)F)c1c(-c2ccccc2)c2cc(Cl)ccc2[nH]c1=O |c:8| Show InChI InChI=1S/C29H21ClF3N3O4/c30-19-10-11-21-20(14-19)26(17-4-2-1-3-5-17)27(28(40)34-21)22-15-23(36(35-22)24(37)12-13-25(38)39)16-6-8-18(9-7-16)29(31,32)33/h1-11,14,23H,12-13,15H2,(H,34,40)(H,38,39)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.90E+4	n/a	n/a	n/a	n/a
Istituto Italiano di Tecnologia Curated by ChEMBL					Assay Description Inhibition of biotinylated BRC4 peptide binding to His-tagged human RAD51 expressed in Escherichia coli Rosetta(DE3) pLysS cells assessed as BRC4-RAD...				J Med Chem 63: 2588-2619 (2020) Article DOI: 10.1021/acs.jmedchem.9b01526
					More data for this Ligand-Target Pair
NMDA receptor subunit N2A (GluN2A) (Rattus norvegicus (Rat))	BDBM50440089 (CHEMBL2426089) Show SMILES OC(=O)CCC(=O)N1N=C(CC1c1ccc(cc1)C(F)(F)F)c1c(-c2ccccc2)c2cc(Cl)ccc2[nH]c1=O |c:8| Show InChI InChI=1S/C29H21ClF3N3O4/c30-19-10-11-21-20(14-19)26(17-4-2-1-3-5-17)27(28(40)34-21)22-15-23(36(35-22)24(37)12-13-25(38)39)16-6-8-18(9-7-16)29(31,32)33/h1-11,14,23H,12-13,15H2,(H,34,40)(H,38,39)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Emory University Curated by ChEMBL					Assay Description Negative allosteric modulation of recombinant rat GluN2A receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp method				J Med Chem 56: 6434-56 (2013) Article DOI: 10.1021/jm400652r BindingDB Entry DOI: 10.7270/Q26H4JTJ
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50440089 (CHEMBL2426089) Show SMILES OC(=O)CCC(=O)N1N=C(CC1c1ccc(cc1)C(F)(F)F)c1c(-c2ccccc2)c2cc(Cl)ccc2[nH]c1=O |c:8| Show InChI InChI=1S/C29H21ClF3N3O4/c30-19-10-11-21-20(14-19)26(17-4-2-1-3-5-17)27(28(40)34-21)22-15-23(36(35-22)24(37)12-13-25(38)39)16-6-8-18(9-7-16)29(31,32)33/h1-11,14,23H,12-13,15H2,(H,34,40)(H,38,39)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
Emory University Curated by ChEMBL					Assay Description Negative allosteric modulation of recombinant rat GluN2B receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp method				J Med Chem 56: 6434-56 (2013) Article DOI: 10.1021/jm400652r BindingDB Entry DOI: 10.7270/Q26H4JTJ
					More data for this Ligand-Target Pair