BDBM50440406 CHEMBL2425590

SMILES: Cn1c(nc2ccccc12)N1CCN(CC1)S(=O)(=O)c1ccc(cc1)C(C)(C)C

InChI Key: InChIKey=ZXXAQIIUZYAKBP-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50440406   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50440406 (CHEMBL2425590) Show SMILES Cn1c(nc2ccccc12)N1CCN(CC1)S(=O)(=O)c1ccc(cc1)C(C)(C)C Show InChI InChI=1S/C22H28N4O2S/c1-22(2,3)17-9-11-18(12-10-17)29(27,28)26-15-13-25(14-16-26)21-23-19-7-5-6-8-20(19)24(21)4/h5-12H,13-16H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Leopold-Franzens-Universit£t Curated by ChEMBL					Assay Description Inhibition of human 11beta-HSD1 expressed in HEK293 cells assessed as [1,2-3H]-cortisone reduction to [1,2,6,7-3H]-cortisol after 10 mins in presence...				Bioorg Med Chem Lett 23: 5397-400 (2013) Article DOI: 10.1016/j.bmcl.2013.07.047 BindingDB Entry DOI: 10.7270/Q2MK6F9R
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