null
SMILES: OCc1cnc(NC(=O)N2CCC(CC2)N2CCc3ccc(F)cc23)s1
InChI Key: InChIKey=AZVQFBDCMPUJLV-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Acyl-CoA desaturase 1 (Rattus norvegicus (Rat)) | BDBM50443718 (CHEMBL3093872 | US9238658, 24) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 88 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research and Development, LLC Curated by ChEMBL | Assay Description Inhibition of SCD1 in Sprague-Dawley rat liver microsomes using Stearoyl-[9,10-3H]-CoA as substrate assessed as [3H2O] generation | Bioorg Med Chem Lett 23: 6773-6 (2013) Article DOI: 10.1016/j.bmcl.2013.09.096 BindingDB Entry DOI: 10.7270/Q21J9C7J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acyl-CoA desaturase 1 (Rattus norvegicus (Rat)) | BDBM50443718 (CHEMBL3093872 | US9238658, 24) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 88 | n/a | n/a | n/a | n/a | n/a | 25 |
Janssen Pharmaceutica NV US Patent | Assay Description The SCD1 enzymatic assay was done in a volume of 50 uL using 10 ug of RLM (prepared as described above) in a 96-well polypropylene plate (enzyme reac... | US Patent US9238658 (2016) BindingDB Entry DOI: 10.7270/Q2930S1D | |||||||||||
More data for this Ligand-Target Pair |