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BDBM50453761 CHEMBL4214749

SMILES: Br.Br.O=C1N(CCNCCCCCCCCCNCCN2C(=O)c3cccc4cccc(C2=O)c34)C(=O)c2cccc3cccc1c23

InChI Key: InChIKey=IFFCSHYGYCAXJH-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50453761   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Putative silent information regulator 2


(Leishmania infantum)		BDBM50453761
PNG
(CHEMBL4214749)
Show SMILES Br.Br.O=C1N(CCNCCCCCCCCCNCCN2C(=O)c3cccc4cccc(C2=O)c34)C(=O)c2cccc3cccc1c23
Show InChI InChI=1S/C37H40N4O4/c42-34-28-16-8-12-26-13-9-17-29(32(26)28)35(43)40(34)24-22-38-20-6-4-2-1-3-5-7-21-39-23-25-41-36(44)30-18-10-14-27-15-11-19-31(33(27)30)37(41)45/h8-19,38-39H,1-7,20-25H2
PDB

KEGG

UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 5.70E+3n/an/an/an/an/an/a



Dipartimento di Chimica e Tecnologie del Farmaco "Sapienza" Universit£ di Roma

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His6-tagged recombinant Leishmania infantum SIR2RP1 expressed in Escherichia coli in presence of NAD+ by fluorimetric method

J Med Chem 60: 4780-4804 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01595
BindingDB Entry DOI: 10.7270/Q2JD50D0
More data for this
Ligand-Target Pair