BDBM50454759 FLESINOXAN::Flesinoxan
SMILES: [H][C@]1(CO)COc2c(O1)cccc2N1CCN(CCNC(=O)c2ccc(F)cc2)CC1
InChI Key: InChIKey=NYSDRDDQELAVKP-SFHVURJKSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat)) | BDBM50454759 (FLESINOXAN | Flesinoxan) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | PubMed | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Solvay Pharma Curated by ChEMBL | Assay Description Inhibition of [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor of rat frontal cortex membranes | Bioorg Med Chem Lett 8: 2457-62 (1999) BindingDB Entry DOI: 10.7270/Q2KS6SQ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat)) | BDBM50454759 (FLESINOXAN | Flesinoxan) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Solvay Pharma Curated by ChEMBL | Assay Description Binding affinity was evaluated by determining in vitro displacement of [3H]-8-OH-DPAT from the central 5-hydroxytryptamine 1A receptor recognition si... | J Med Chem 40: 300-12 (1997) Article DOI: 10.1021/jm960496o BindingDB Entry DOI: 10.7270/Q27W6B96 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM50454759 (FLESINOXAN | Flesinoxan) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | 140 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Solvay Pharma Curated by ChEMBL | Assay Description In vitro displacement of [3H]-spiperone from Dopamine receptor D2 binding site in rat striatum. | J Med Chem 40: 300-12 (1997) Article DOI: 10.1021/jm960496o BindingDB Entry DOI: 10.7270/Q27W6B96 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM50454759 (FLESINOXAN | Flesinoxan) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | n/a | 6.60 | n/a | n/a | n/a | n/a |
Solvay Pharma Curated by ChEMBL | Assay Description Compound was tested for its potency against human 5-hydroxytryptamine 1A receptor expressed in CHO cells | Bioorg Med Chem Lett 8: 2457-62 (1999) BindingDB Entry DOI: 10.7270/Q2KS6SQ1 | |||||||||||
More data for this Ligand-Target Pair |