BDBM50456075 CHEMBL4216354

SMILES: C[C@H](Oc1ccc(F)c(F)c1F)C(=O)Nc1ccc2oc(nc2c1)-c1ccc(cc1)C#N

InChI Key: InChIKey=HXEVVVKRKUTSHY-LBPRGKRZSA-N

Data: 2 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50456075   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Inosine-5'-monophosphate dehydrogenase (IMPDH) (Homo sapiens (Human))	BDBM50456075 (CHEMBL4216354) Show SMILES C[C@H](Oc1ccc(F)c(F)c1F)C(=O)Nc1ccc2oc(nc2c1)-c1ccc(cc1)C#N |r| Show InChI InChI=1S/C23H14F3N3O3/c1-12(31-19-9-7-16(24)20(25)21(19)26)22(30)28-15-6-8-18-17(10-15)29-23(32-18)14-4-2-13(11-27)3-5-14/h2-10,12H,1H3,(H,28,30)/t12-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	>5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Allergy and Infectious Diseases Curated by ChEMBL					Assay Description Inhibition of human IMPDH2 using IMP as substrate by spectrophotometric method				J Med Chem 61: 4739-4756 (2018) Article DOI: 10.1021/acs.jmedchem.7b01839 BindingDB Entry DOI: 10.7270/Q29889M0
					More data for this Ligand-Target Pair
GMP reductase 2 (Homo sapiens)	BDBM50456075 (CHEMBL4216354) Show SMILES C[C@H](Oc1ccc(F)c(F)c1F)C(=O)Nc1ccc2oc(nc2c1)-c1ccc(cc1)C#N |r| Show InChI InChI=1S/C23H14F3N3O3/c1-12(31-19-9-7-16(24)20(25)21(19)26)22(30)28-15-6-8-18-17(10-15)29-23(32-18)14-4-2-13(11-27)3-5-14/h2-10,12H,1H3,(H,28,30)/t12-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	>5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Allergy and Infectious Diseases Curated by ChEMBL					Assay Description Inhibition of human GMPR2 using GMP as substrate by spectrophotometric method				J Med Chem 61: 4739-4756 (2018) Article DOI: 10.1021/acs.jmedchem.7b01839 BindingDB Entry DOI: 10.7270/Q29889M0
					More data for this Ligand-Target Pair