BindingDB PrimarySearch

BDBM50458225 CIPROXIFAN::Ciproxifan

SMILES: O=C(C1CC1)c1ccc(OCCCc2c[nH]cn2)cc1

InChI Key: InChIKey=ACQBHJXEAYTHCY-UHFFFAOYSA-N

Data: 3 KI 10 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50458225
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Histamine H3 receptor (Homo sapiens (Human))	BDBM50458225 (CIPROXIFAN \| Ciproxifan) Show SMILES O=C(C1CC1)c1ccc(OCCCc2c[nH]cn2)cc1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	46	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Julius Maximilian University of W£rzburg Curated by ChEMBL					Assay Description Inhibition of human histamine H3 receptor				Eur J Med Chem 180: 690-706 (2019) Article DOI: 10.1016/j.ejmech.2019.07.040
Julius Maximilian University of W£rzburg Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50458225 (CIPROXIFAN \| Ciproxifan) Show SMILES O=C(C1CC1)c1ccc(OCCCc2c[nH]cn2)cc1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	46	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Heinrich Heine University Duesseldorf Curated by ChEMBL					Assay Description Binding affinity to human H3R				Eur J Med Chem 148: 487-497 (2018) Article DOI: 10.1016/j.ejmech.2018.02.015 BindingDB Entry DOI: 10.7270/Q2Z89G1Q
Heinrich Heine University Duesseldorf Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50458225 (CIPROXIFAN \| Ciproxifan) Show SMILES O=C(C1CC1)c1ccc(OCCCc2c[nH]cn2)cc1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	46	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
CSIR-Central Drug Research Institute Curated by ChEMBL					Assay Description Displacement of [3H]-N-alpha-methylhistamine from human H3R expressed in HEK293 cell membranes incubated for 90 mins by liquid scintillation counting...				Bioorg Med Chem 27: 895-930 (2019) Article DOI: 10.1016/j.bmc.2019.01.025
CSIR-Central Drug Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50458225 (CIPROXIFAN \| Ciproxifan) Show SMILES O=C(C1CC1)c1ccc(OCCCc2c[nH]cn2)cc1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem		49	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50458225 (CIPROXIFAN \| Ciproxifan) Show SMILES O=C(C1CC1)c1ccc(OCCCc2c[nH]cn2)cc1 Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem		63	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Acetylcholinesterase (Homo sapiens (Human))	BDBM50458225 (CIPROXIFAN \| Ciproxifan) Show SMILES O=C(C1CC1)c1ccc(OCCCc2c[nH]cn2)cc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	8.61E+4	n/a	n/a	n/a	n/a	n/a	n/a
Julius Maximilian University of W£rzburg Curated by ChEMBL					Assay Description Inhibition of human AChE				Eur J Med Chem 180: 690-706 (2019) Article DOI: 10.1016/j.ejmech.2019.07.040
Julius Maximilian University of W£rzburg Curated by ChEMBL					More data for this Ligand-Target Pair
Amine oxidase (flavin-containing) A (Homo sapiens (Human))	BDBM50458225 (CIPROXIFAN \| Ciproxifan) Show SMILES O=C(C1CC1)c1ccc(OCCCc2c[nH]cn2)cc1 Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.14E+4	n/a	n/a	n/a	n/a	n/a	n/a
Julius Maximilian University of W£rzburg Curated by ChEMBL					Assay Description Inhibition of human MAOA				Eur J Med Chem 180: 690-706 (2019) Article DOI: 10.1016/j.ejmech.2019.07.040
Julius Maximilian University of W£rzburg Curated by ChEMBL					More data for this Ligand-Target Pair
Cholinesterases; ACHE & BCHE (Homo sapiens (Human))	BDBM50458225 (CIPROXIFAN \| Ciproxifan) Show SMILES O=C(C1CC1)c1ccc(OCCCc2c[nH]cn2)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	7.73E+4	n/a	n/a	n/a	n/a	n/a	n/a
Julius Maximilian University of W£rzburg Curated by ChEMBL					Assay Description Inhibition of human BChE				Eur J Med Chem 180: 690-706 (2019) Article DOI: 10.1016/j.ejmech.2019.07.040
Julius Maximilian University of W£rzburg Curated by ChEMBL					More data for this Ligand-Target Pair
Amine oxidase [flavin-containing] B (Homo sapiens (Human))	BDBM50458225 (CIPROXIFAN \| Ciproxifan) Show SMILES O=C(C1CC1)c1ccc(OCCCc2c[nH]cn2)cc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Julius Maximilian University of W£rzburg Curated by ChEMBL					Assay Description Inhibition of human MAOB				Eur J Med Chem 180: 690-706 (2019) Article DOI: 10.1016/j.ejmech.2019.07.040
Julius Maximilian University of W£rzburg Curated by ChEMBL					More data for this Ligand-Target Pair
Amine oxidase (flavin-containing) A (Homo sapiens (Human))	BDBM50458225 (CIPROXIFAN \| Ciproxifan) Show SMILES O=C(C1CC1)c1ccc(OCCCc2c[nH]cn2)cc1 Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.14E+4	n/a	n/a	n/a	n/a	n/a	n/a
CSIR-Central Drug Research Institute Curated by ChEMBL					Assay Description Inhibition of recombinant human MAOA expressed in baculovirus infected BTI insect cells using p-tyramine as substrate by Amplex red reagent/horseradi...				Bioorg Med Chem 27: 895-930 (2019) Article DOI: 10.1016/j.bmc.2019.01.025
CSIR-Central Drug Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Cholinesterases; ACHE & BCHE (Homo sapiens (Human))	BDBM50458225 (CIPROXIFAN \| Ciproxifan) Show SMILES O=C(C1CC1)c1ccc(OCCCc2c[nH]cn2)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	7.73E+4	n/a	n/a	n/a	n/a	n/a	n/a
CSIR-Central Drug Research Institute Curated by ChEMBL					Assay Description Inhibition of human plasma butyrylcholinesterase by Ellman's method				Bioorg Med Chem 27: 895-930 (2019) Article DOI: 10.1016/j.bmc.2019.01.025
CSIR-Central Drug Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Acetylcholinesterase (Homo sapiens (Human))	BDBM50458225 (CIPROXIFAN \| Ciproxifan) Show SMILES O=C(C1CC1)c1ccc(OCCCc2c[nH]cn2)cc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	8.61E+4	n/a	n/a	n/a	n/a	n/a	n/a
CSIR-Central Drug Research Institute Curated by ChEMBL					Assay Description Inhibition of human acetylcholinesterase expressed in HEK 293 cells using acetylthiocholine iodide as substrate by Ellman's method				Bioorg Med Chem 27: 895-930 (2019) Article DOI: 10.1016/j.bmc.2019.01.025
CSIR-Central Drug Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Amine oxidase [flavin-containing] B (Homo sapiens (Human))	BDBM50458225 (CIPROXIFAN \| Ciproxifan) Show SMILES O=C(C1CC1)c1ccc(OCCCc2c[nH]cn2)cc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
CSIR-Central Drug Research Institute Curated by ChEMBL					Assay Description Inhibition of recombinant human MAOB expressed in baculovirus infected BTI insect cells using p-tyramine as substrate by Amplex red reagent/horseradi...				Bioorg Med Chem 27: 895-930 (2019) Article DOI: 10.1016/j.bmc.2019.01.025
CSIR-Central Drug Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Amine oxidase (flavin-containing) A (Homo sapiens (Human))	BDBM50458225 (CIPROXIFAN \| Ciproxifan) Show SMILES O=C(C1CC1)c1ccc(OCCCc2c[nH]cn2)cc1 Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Heinrich Heine University Duesseldorf Curated by ChEMBL					Assay Description Inhibition of human MAO-A expressed in baculovirus infected insect cell membranes using kynuramine as substrate up to 30 mins by spectrophotometric m...				Eur J Med Chem 148: 487-497 (2018) Article DOI: 10.1016/j.ejmech.2018.02.015 BindingDB Entry DOI: 10.7270/Q2Z89G1Q
Heinrich Heine University Duesseldorf Curated by ChEMBL					More data for this Ligand-Target Pair
Amine oxidase [flavin-containing] B (Homo sapiens (Human))	BDBM50458225 (CIPROXIFAN \| Ciproxifan) Show SMILES O=C(C1CC1)c1ccc(OCCCc2c[nH]cn2)cc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Heinrich Heine University Duesseldorf Curated by ChEMBL					Assay Description Inhibition of human MAO-B expressed in baculovirus infected insect cell membranes using kynuramine as substrate up to 30 mins by spectrophotometric m...				Eur J Med Chem 148: 487-497 (2018) Article DOI: 10.1016/j.ejmech.2018.02.015 BindingDB Entry DOI: 10.7270/Q2Z89G1Q
Heinrich Heine University Duesseldorf Curated by ChEMBL					More data for this Ligand-Target Pair