null
SMILES: COc1nc(C)c(N2CCCn3c2nc2c(Cl)ccc([C@@H](OC(F)F)C(F)(F)F)c32)c(C)n1
InChI Key: InChIKey=SJCKNNGKORXNRE-MRXNPFEDSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human)) | BDBM50460168 (CHEMBL4225709) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Ltd. Curated by ChEMBL | Assay Description Antagonist activity at human CRF1 receptor expressed in CHO cells assessed as inhibition of human CRF-stimulated cAMP accumulation after 4 hrs by luc... | Bioorg Med Chem 26: 2229-2250 (2018) Article DOI: 10.1016/j.bmc.2018.01.020 BindingDB Entry DOI: 10.7270/Q2474DG1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Corticotropin-releasing factor receptor 2 (Homo sapiens (Human)) | BDBM50460168 (CHEMBL4225709) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Ltd. Curated by ChEMBL | Assay Description Antagonist activity at human CRF2alpha receptor expressed in CHO cells assessed as inhibition of human CRF-stimulated cAMP accumulation after 4 hrs b... | Bioorg Med Chem 26: 2229-2250 (2018) Article DOI: 10.1016/j.bmc.2018.01.020 BindingDB Entry DOI: 10.7270/Q2474DG1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Corticotropin-releasing factor receptor 2 (Homo sapiens (Human)) | BDBM50460168 (CHEMBL4225709) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Ltd. Curated by ChEMBL | Assay Description Antagonist activity at human CRF2beta receptor expressed in CHO cells assessed as inhibition of human CRF-stimulated cAMP accumulation after 4 hrs by... | Bioorg Med Chem 26: 2229-2250 (2018) Article DOI: 10.1016/j.bmc.2018.01.020 BindingDB Entry DOI: 10.7270/Q2474DG1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human)) | BDBM50460168 (CHEMBL4225709) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 58 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Ltd. Curated by ChEMBL | Assay Description Displacement of ovine [125-I]-CRF from human CRF1 receptor expressed in CHO cell membranes after 1.5 hrs by liquid scintillation counting method | Bioorg Med Chem 26: 2229-2250 (2018) Article DOI: 10.1016/j.bmc.2018.01.020 BindingDB Entry DOI: 10.7270/Q2474DG1 | |||||||||||
More data for this Ligand-Target Pair |