BDBM50462633 CHEMBL587965
SMILES: CNC(=O)c1ccccc1Nc1nc(Nc2cccc(CS(C)(=O)=O)c2)ncc1C
InChI Key: InChIKey=AKHLCKMEVWGDGL-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tyrosine- and threonine-specific cdc2-inhibitory kinase (Homo sapiens (Human)) | BDBM50462633 (CHEMBL587965) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Martin-Luther-University Halle-Wittenberg Curated by ChEMBL | Assay Description Displacement of (6-FAM)KI(pY)VV from full length PKMYT1 (unknown origin) by fluorescence polarization immuno assay | Eur J Med Chem 161: 479-492 (2019) Article DOI: 10.1016/j.ejmech.2018.10.050 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine- and threonine-specific cdc2-inhibitory kinase (Homo sapiens (Human)) | BDBM50462633 (CHEMBL587965) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Martin-Luther-University Halle-Wittenberg Curated by ChEMBL | Assay Description Inhibition of human full length PKMYT1 expressed in HEK293 cells using EFS (247 to 259 residues) as substrate after 1 hr by fluorescence polarization... | Bioorg Med Chem 26: 4014-4024 (2018) Article DOI: 10.1016/j.bmc.2018.06.027 BindingDB Entry DOI: 10.7270/Q29Z97K0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine- and threonine-specific cdc2-inhibitory kinase (Homo sapiens (Human)) | BDBM50462633 (CHEMBL587965) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 104 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Martin-Luther-University Halle-Wittenberg Curated by ChEMBL | Assay Description Displacement of (6-FAM)KI(pY)VV from PKMYT1 kinase domain (unknown origin) by fluorescence polarization binding assay | Eur J Med Chem 161: 479-492 (2019) Article DOI: 10.1016/j.ejmech.2018.10.050 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine- and threonine-specific cdc2-inhibitory kinase (Homo sapiens (Human)) | BDBM50462633 (CHEMBL587965) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 104 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Martin-Luther-University Halle-Wittenberg Curated by ChEMBL | Assay Description Inhibition of N-[3',6'-dihydroxy-3-oxo-3H-spiro(2-benzofuran-1,9'-xanthen)-5-yl]-N'-[2-(4-{4-[N-(2-chloro-6-methylphenyl)-5-carboxamido]-thiazol-2-yl... | Bioorg Med Chem 26: 4014-4024 (2018) Article DOI: 10.1016/j.bmc.2018.06.027 BindingDB Entry DOI: 10.7270/Q29Z97K0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine- and threonine-specific cdc2-inhibitory kinase (Homo sapiens (Human)) | BDBM50462633 (CHEMBL587965) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 105 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Martin-Luther-University Halle-Wittenberg Curated by ChEMBL | Assay Description Displacement of (6-FAM)KI(pY)VV from PKMYT1 kinase domain (unknown origin) by fluorescence polarization binding assay | Eur J Med Chem 161: 479-492 (2019) Article DOI: 10.1016/j.ejmech.2018.10.050 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine- and threonine-specific cdc2-inhibitory kinase (Homo sapiens (Human)) | BDBM50462633 (CHEMBL587965) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 115 | n/a | n/a | n/a | n/a | n/a | n/a |
Martin-Luther-University Halle-Wittenberg Curated by ChEMBL | Assay Description Displacement of (6-FAM)KI(pY)VV from full length PKMYT1 (unknown origin) by fluorescence polarization immuno assay | Eur J Med Chem 161: 479-492 (2019) Article DOI: 10.1016/j.ejmech.2018.10.050 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine- and threonine-specific cdc2-inhibitory kinase (Homo sapiens (Human)) | BDBM50462633 (CHEMBL587965) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 151 | n/a | n/a | n/a | n/a | n/a | n/a |
Martin-Luther-University Halle-Wittenberg Curated by ChEMBL | Assay Description Inhibition of N-[3',6'-dihydroxy-3-oxo-3H-spiro(2-benzofuran-1,9'-xanthen)-5-yl]-N'-[2-(4-{4-[N-(2-chloro-6-methylphenyl)-5-carboxamido]-thiazol-2-yl... | Bioorg Med Chem 26: 4014-4024 (2018) Article DOI: 10.1016/j.bmc.2018.06.027 BindingDB Entry DOI: 10.7270/Q29Z97K0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine- and threonine-specific cdc2-inhibitory kinase (Homo sapiens (Human)) | BDBM50462633 (CHEMBL587965) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 115 | n/a | n/a | n/a | n/a | n/a | n/a |
Martin-Luther-University Halle-Wittenberg Curated by ChEMBL | Assay Description Inhibition of human full length PKMYT1 expressed in HEK293 cells using EFS (247 to 259 residues) as substrate after 1 hr by fluorescence polarization... | Bioorg Med Chem 26: 4014-4024 (2018) Article DOI: 10.1016/j.bmc.2018.06.027 BindingDB Entry DOI: 10.7270/Q29Z97K0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine- and threonine-specific cdc2-inhibitory kinase (Homo sapiens (Human)) | BDBM50462633 (CHEMBL587965) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 151 | n/a | n/a | n/a | n/a | n/a | n/a |
Martin-Luther-University Halle-Wittenberg Curated by ChEMBL | Assay Description Displacement of (6-FAM)KI(pY)VV from PKMYT1 kinase domain (unknown origin) by fluorescence polarization binding assay | Eur J Med Chem 161: 479-492 (2019) Article DOI: 10.1016/j.ejmech.2018.10.050 | |||||||||||
More data for this Ligand-Target Pair |