BDBM50463142 CHEMBL4238441

SMILES: CCOC(=O)\C=C\C(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1

InChI Key: InChIKey=WISLRZADXFYSET-DYQZOYDYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50463142   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Rhodesain (Trypanosoma brucei rhodesiense)	BDBM50463142 (CHEMBL4238441) Show SMILES CCOC(=O)\C=C\C(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 |r| Show InChI InChI=1S/C28H34N2O6/c1-4-35-26(32)16-15-25(31)23(17-20(2)3)29-27(33)24(18-21-11-7-5-8-12-21)30-28(34)36-19-22-13-9-6-10-14-22/h5-16,20,23-24H,4,17-19H2,1-3H3,(H,29,33)(H,30,34)/b16-15+/t23-,24+/m1/s1	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Universitat Jaume I Curated by ChEMBL					Assay Description Inhibition of Trypanosoma brucei rhodesiense rhodesain using Cbz-Phe-Arg-AMC as substrate measured for 30 mins by fluorescence method				Bioorg Med Chem 26: 4624-4634 (2018) Article DOI: 10.1016/j.bmc.2018.07.015 BindingDB Entry DOI: 10.7270/Q29S1TPM
					More data for this Ligand-Target Pair
Cathepsin B (Homo sapiens (Human))	BDBM50463142 (CHEMBL4238441) Show SMILES CCOC(=O)\C=C\C(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 |r| Show InChI InChI=1S/C28H34N2O6/c1-4-35-26(32)16-15-25(31)23(17-20(2)3)29-27(33)24(18-21-11-7-5-8-12-21)30-28(34)36-19-22-13-9-6-10-14-22/h5-16,20,23-24H,4,17-19H2,1-3H3,(H,29,33)(H,30,34)/b16-15+/t23-,24+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
Universitat Jaume I Curated by ChEMBL					Assay Description Inhibition of human cathepsin B using Cbz-Phe-Arg-AMC as substrate				Bioorg Med Chem 26: 4624-4634 (2018) Article DOI: 10.1016/j.bmc.2018.07.015 BindingDB Entry DOI: 10.7270/Q29S1TPM
					More data for this Ligand-Target Pair
Cruzipain (Trypanosoma cruzi)	BDBM50463142 (CHEMBL4238441) Show SMILES CCOC(=O)\C=C\C(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 |r| Show InChI InChI=1S/C28H34N2O6/c1-4-35-26(32)16-15-25(31)23(17-20(2)3)29-27(33)24(18-21-11-7-5-8-12-21)30-28(34)36-19-22-13-9-6-10-14-22/h5-16,20,23-24H,4,17-19H2,1-3H3,(H,29,33)(H,30,34)/b16-15+/t23-,24+/m1/s1	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Universitat Jaume I Curated by ChEMBL					Assay Description Inhibition of Trypanosoma cruzi cruzain				Bioorg Med Chem 26: 4624-4634 (2018) Article DOI: 10.1016/j.bmc.2018.07.015 BindingDB Entry DOI: 10.7270/Q29S1TPM
					More data for this Ligand-Target Pair
Procathepsin L (Homo sapiens (Human))	BDBM50463142 (CHEMBL4238441) Show SMILES CCOC(=O)\C=C\C(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 |r| Show InChI InChI=1S/C28H34N2O6/c1-4-35-26(32)16-15-25(31)23(17-20(2)3)29-27(33)24(18-21-11-7-5-8-12-21)30-28(34)36-19-22-13-9-6-10-14-22/h5-16,20,23-24H,4,17-19H2,1-3H3,(H,29,33)(H,30,34)/b16-15+/t23-,24+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Universitat Jaume I Curated by ChEMBL					Assay Description Inhibition of human cathepsin L using Cbz-Phe-Arg-AMC as substrate				Bioorg Med Chem 26: 4624-4634 (2018) Article DOI: 10.1016/j.bmc.2018.07.015 BindingDB Entry DOI: 10.7270/Q29S1TPM
					More data for this Ligand-Target Pair