BDBM50463845 CHEMBL4242403

SMILES: FC(F)(F)c1cccc(c1)[C@H](NC(=O)c1ccc2cccnc2c1)c1ncccc1C(F)(F)F

InChI Key: InChIKey=YNRFVYBOUKLFOD-FQEVSTJZSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50463845   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Transient receptor potential cation channel subfamily M member 8 (TRPM8) (Homo sapiens (Human))	BDBM50463845 (CHEMBL4242403) Show SMILES FC(F)(F)c1cccc(c1)[C@H](NC(=O)c1ccc2cccnc2c1)c1ncccc1C(F)(F)F |r| Show InChI InChI=1S/C24H15F6N3O/c25-23(26,27)17-6-1-4-15(12-17)20(21-18(24(28,29)30)7-3-11-32-21)33-22(34)16-9-8-14-5-2-10-31-19(14)13-16/h1-13,20H,(H,33,34)/t20-/m0/s1	KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	157	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Antagonist activity at human TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 ...				J Med Chem 61: 8186-8201 (2018) Article DOI: 10.1021/acs.jmedchem.8b00518 BindingDB Entry DOI: 10.7270/Q2TH8QCW
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (Mus musculus)	BDBM50463845 (CHEMBL4242403) Show SMILES FC(F)(F)c1cccc(c1)[C@H](NC(=O)c1ccc2cccnc2c1)c1ncccc1C(F)(F)F |r| Show InChI InChI=1S/C24H15F6N3O/c25-23(26,27)17-6-1-4-15(12-17)20(21-18(24(28,29)30)7-3-11-32-21)33-22(34)16-9-8-14-5-2-10-31-19(14)13-16/h1-13,20H,(H,33,34)/t20-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	218	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Antagonist activity at mouse TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 ...				J Med Chem 61: 8186-8201 (2018) Article DOI: 10.1021/acs.jmedchem.8b00518 BindingDB Entry DOI: 10.7270/Q2TH8QCW
					More data for this Ligand-Target Pair