BDBM50463877 CHEMBL4238688

SMILES: COc1ccc(cc1)[C@H](NC(=O)c1ccc2cccnc2c1)c1ncccc1C(F)(F)F

InChI Key: InChIKey=SNGJRCXXXCPGOB-NRFANRHFSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50463877   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Transient receptor potential cation channel subfamily M member 8 (TRPM8) (Homo sapiens (Human))	BDBM50463877 (CHEMBL4238688) Show SMILES COc1ccc(cc1)[C@H](NC(=O)c1ccc2cccnc2c1)c1ncccc1C(F)(F)F |r| Show InChI InChI=1S/C24H18F3N3O2/c1-32-18-10-8-16(9-11-18)21(22-19(24(25,26)27)5-3-13-29-22)30-23(31)17-7-6-15-4-2-12-28-20(15)14-17/h2-14,21H,1H3,(H,30,31)/t21-/m0/s1	KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	95	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Antagonist activity at human TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 ...				J Med Chem 61: 8186-8201 (2018) Article DOI: 10.1021/acs.jmedchem.8b00518 BindingDB Entry DOI: 10.7270/Q2TH8QCW
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (Mus musculus)	BDBM50463877 (CHEMBL4238688) Show SMILES COc1ccc(cc1)[C@H](NC(=O)c1ccc2cccnc2c1)c1ncccc1C(F)(F)F |r| Show InChI InChI=1S/C24H18F3N3O2/c1-32-18-10-8-16(9-11-18)21(22-19(24(25,26)27)5-3-13-29-22)30-23(31)17-7-6-15-4-2-12-28-20(15)14-17/h2-14,21H,1H3,(H,30,31)/t21-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	224	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Antagonist activity at mouse TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 ...				J Med Chem 61: 8186-8201 (2018) Article DOI: 10.1021/acs.jmedchem.8b00518 BindingDB Entry DOI: 10.7270/Q2TH8QCW
					More data for this Ligand-Target Pair