BDBM50468902 CHEMBL4288881
SMILES: CO[C@H](C)[C@@H]1N(C)C(=O)[C@@H](NC(=O)[C@H](C)N(C)C(=O)[C@H](C)NC(=O)C(=C)N(C)C(=O)[C@@H](Cc2ccccc2)OC(=O)[C@@H](NC(C)=O)[C@@H](C)OC1=O)[C@H](OC(=O)[C@@H](NC(C)=O)[C@H](O)C(C)C)C(C)C
InChI Key: InChIKey=QVYLWCAYZGFGNF-WBWCVGBTSA-N
Data: 7 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Guanine nucleotide-binding protein subunit alpha-11 (Homo sapiens) | BDBM50468902![]() (CHEMBL4288881) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 155 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen Curated by ChEMBL | Assay Description Inhibition of recombinant human Gq/11 coupled N-terminal 3His-tagged M1 receptor expressed in CHOK1 cells assessed as reduction in carbachol-induced ... | Eur J Med Chem 156: 847-860 (2018) Article DOI: 10.1016/j.ejmech.2018.07.023 BindingDB Entry DOI: 10.7270/Q2BP05GZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (Homo sapiens) | BDBM50468902![]() (CHEMBL4288881) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen Curated by ChEMBL | Assay Description Inhibition of Gs coupled adrenergic beta2 receptor in HEK293 cells assessed as reduction in isoproterenol-induced cAMP production pretreated for 1 hr... | Eur J Med Chem 156: 847-860 (2018) Article DOI: 10.1016/j.ejmech.2018.07.023 BindingDB Entry DOI: 10.7270/Q2BP05GZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Guanine nucleotide-binding protein G(o) subunit alpha (Rattus norvegicus) | BDBM50468902![]() (CHEMBL4288881) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen Curated by ChEMBL | Assay Description Inhibition of recombinant rat Gi coupled mGlu2 receptor expressed in CHO cells assessed as suppression of L-glutamate-induced decrease in cAMP level ... | Eur J Med Chem 156: 847-860 (2018) Article DOI: 10.1016/j.ejmech.2018.07.023 BindingDB Entry DOI: 10.7270/Q2BP05GZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Guanine nucleotide-binding protein G(q) subunit alpha (Homo sapiens) | BDBM50468902![]() (CHEMBL4288881) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University Curated by ChEMBL | Assay Description Inhibition of G-alphaq/11 in human platelet rich plasma assessed as inhibition of ADP-mediated calcium ion mobilization | J Med Chem 63: 5013-5030 (2020) Article DOI: 10.1021/acs.jmedchem.9b01452 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Guanine nucleotide binding protein q polypeptide (Cricetulus griseus) | BDBM50468902![]() (CHEMBL4288881) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 95 | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University Curated by ChEMBL | Assay Description Inhibition of Gq-mediated signalling in CHOK1 cells stably expressing M1 muscarinic receptor assessed as inhibition of carbachol-induced IP1 producti... | J Med Chem 63: 5013-5030 (2020) Article DOI: 10.1021/acs.jmedchem.9b01452 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
GNAQ/GNA11 (Homo sapiens) | BDBM50468902![]() (CHEMBL4288881) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University Curated by ChEMBL | Assay Description Inhibition of G-alphaq/11 in human platelet rich plasma assessed as inhibition of ADP-mediated platelet aggregation | J Med Chem 63: 5013-5030 (2020) Article DOI: 10.1021/acs.jmedchem.9b01452 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Guanine nucleotide-binding protein subunit alpha-11 (Homo sapiens) | BDBM50468902![]() (CHEMBL4288881) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen Curated by ChEMBL | Assay Description Inhibition of recombinant human Gq/11 coupled N-terminal 3His-tagged M1 receptor expressed in CHOK1 cells assessed as reduction in carbachol-induced ... | Eur J Med Chem 156: 847-860 (2018) Article DOI: 10.1016/j.ejmech.2018.07.023 BindingDB Entry DOI: 10.7270/Q2BP05GZ | |||||||||||
More data for this Ligand-Target Pair |