null
SMILES: [H][C@@]12C(COC1=O)C(OC1OC3COC(C)OC3C(O)C1N)c1cc3OCOc3cc1[C@H]2c1cc(OC)c(O)c(OC)c1
InChI Key: InChIKey=FBXXLRBLSSYWAA-WXRMPKHTSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DNA topoisomerase 2-alpha/2-beta (Homo sapiens (Human)) | BDBM50471913![]() (NK-611) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 5.60E+4 | n/a | n/a | n/a | n/a |
UMR 176 CNRS/Institut Curie Curated by ChEMBL | Assay Description In vitro inhibitory activity against DNA topoisomerase II | J Med Chem 41: 4475-85 (1998) Article DOI: 10.1021/jm9800752 BindingDB Entry DOI: 10.7270/Q2251MZB | |||||||||||
More data for this Ligand-Target Pair |