Found 3 hits for monomerid = 50473358 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50473358
(CHEMBL81960)Show SMILES COc1ccc(cc1OC)C1=NN(Cc2ccccc2)C(=O)C2CCCCC12 |t:11| Show InChI InChI=1S/C23H26N2O3/c1-27-20-13-12-17(14-21(20)28-2)22-18-10-6-7-11-19(18)23(26)25(24-22)15-16-8-4-3-5-9-16/h3-5,8-9,12-14,18-19H,6-7,10-11,15H2,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 7.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Vrije Universiteit
Curated by ChEMBL
| Assay Description
Inhibition of phosphodiesterase 4 (PDE4) in human neutrophils |
J Med Chem 44: 2523-35 (2001)
Article DOI: 10.1021/jm010838c
BindingDB Entry DOI: 10.7270/Q23N2644 |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50473358
(CHEMBL81960)Show SMILES COc1ccc(cc1OC)C1=NN(Cc2ccccc2)C(=O)C2CCCCC12 |t:11| Show InChI InChI=1S/C23H26N2O3/c1-27-20-13-12-17(14-21(20)28-2)22-18-10-6-7-11-19(18)23(26)25(24-22)15-16-8-4-3-5-9-16/h3-5,8-9,12-14,18-19H,6-7,10-11,15H2,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 7.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Vrije Universiteit
Curated by ChEMBL
| Assay Description
Inhibitory concentration against phosphodiesterase 4 (PDE4) in cytosol of human neutrophils |
J Med Chem 45: 2520-5 (2002)
Article DOI: 10.1021/jm0110340
BindingDB Entry DOI: 10.7270/Q2862K56 |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B
(Homo sapiens (Human)) | BDBM50473358
(CHEMBL81960)Show SMILES COc1ccc(cc1OC)C1=NN(Cc2ccccc2)C(=O)C2CCCCC12 |t:11| Show InChI InChI=1S/C23H26N2O3/c1-27-20-13-12-17(14-21(20)28-2)22-18-10-6-7-11-19(18)23(26)25(24-22)15-16-8-4-3-5-9-16/h3-5,8-9,12-14,18-19H,6-7,10-11,15H2,1-2H3 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | <3.16E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Vrije Universiteit
Curated by ChEMBL
| Assay Description
Inhibitory activity of the against phosphodiesterase 3 (PDE3); No significant inhibitory activity at pIC50 |
J Med Chem 44: 2523-35 (2001)
Article DOI: 10.1021/jm010838c
BindingDB Entry DOI: 10.7270/Q23N2644 |
More data for this
Ligand-Target Pair | |
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