BDBM50475340 METHIMEPIP::Methimepip

SMILES: CN1CCC(Cc2c[nH]cn2)CC1

InChI Key: InChIKey=KIAVPENCSGKVQP-UHFFFAOYSA-N

Data: 6 KI  3 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50475340   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histamine H3 receptor (Homo sapiens (Human))	BDBM50475340 (METHIMEPIP | Methimepip) Show SMILES CN1CCC(Cc2c[nH]cn2)CC1 Show InChI InChI=1S/C10H17N3/c1-13-4-2-9(3-5-13)6-10-7-11-8-12-10/h7-9H,2-6H2,1H3,(H,11,12)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vrije Universiteit Amsterdam Curated by ChEMBL					Assay Description Displacement of [3H]N-R-methylhistamine binding to SK-N-MC cell membranes expressing human H3 receptor				J Med Chem 48: 2100-7 (2005) Article DOI: 10.1021/jm049475h BindingDB Entry DOI: 10.7270/Q28K7CVC
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50475340 (METHIMEPIP | Methimepip) Show SMILES CN1CCC(Cc2c[nH]cn2)CC1 Show InChI InChI=1S/C10H17N3/c1-13-4-2-9(3-5-13)6-10-7-11-8-12-10/h7-9H,2-6H2,1H3,(H,11,12)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Regensburg Curated by ChEMBL					Assay Description Displacement of [3H]Nalpha-methylhistamine from human histamine H3 receptor expressed in human SK-N-MC cells				Bioorg Med Chem Lett 20: 7191-9 (2010) Article DOI: 10.1016/j.bmcl.2010.10.041 BindingDB Entry DOI: 10.7270/Q2Q81GX5
					More data for this Ligand-Target Pair
Histamine receptor (H3 and H4) (Homo sapiens (Human))	BDBM50475340 (METHIMEPIP | Methimepip) Show SMILES CN1CCC(Cc2c[nH]cn2)CC1 Show InChI InChI=1S/C10H17N3/c1-13-4-2-9(3-5-13)6-10-7-11-8-12-10/h7-9H,2-6H2,1H3,(H,11,12)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Regensburg Curated by ChEMBL					Assay Description Displacement of [3H]-histamine from human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19, Galphai2, Gbeta1gamma2				Bioorg Med Chem Lett 20: 7191-9 (2010) Article DOI: 10.1016/j.bmcl.2010.10.041 BindingDB Entry DOI: 10.7270/Q2Q81GX5
					More data for this Ligand-Target Pair
Histamine receptor (H3 and H4) (Homo sapiens (Human))	BDBM50475340 (METHIMEPIP | Methimepip) Show SMILES CN1CCC(Cc2c[nH]cn2)CC1 Show InChI InChI=1S/C10H17N3/c1-13-4-2-9(3-5-13)6-10-7-11-8-12-10/h7-9H,2-6H2,1H3,(H,11,12)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vrije Universiteit Amsterdam Curated by ChEMBL					Assay Description Displacement of [3H]histamine binding to SK-N-MC cell membranes expressing human histamine H4 receptor				J Med Chem 48: 2100-7 (2005) Article DOI: 10.1021/jm049475h BindingDB Entry DOI: 10.7270/Q28K7CVC
					More data for this Ligand-Target Pair
Histamine H1 receptor (Homo sapiens (Human))	BDBM50475340 (METHIMEPIP | Methimepip) Show SMILES CN1CCC(Cc2c[nH]cn2)CC1 Show InChI InChI=1S/C10H17N3/c1-13-4-2-9(3-5-13)6-10-7-11-8-12-10/h7-9H,2-6H2,1H3,(H,11,12)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	<1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vrije Universiteit Amsterdam Curated by ChEMBL					Assay Description Displacement of [3H]mepyramine binding to COS-7 cell membranes expressing human histamine H1 receptor				J Med Chem 48: 2100-7 (2005) Article DOI: 10.1021/jm049475h BindingDB Entry DOI: 10.7270/Q28K7CVC
					More data for this Ligand-Target Pair
Histamine H2 receptor (Homo sapiens (Human))	BDBM50475340 (METHIMEPIP | Methimepip) Show SMILES CN1CCC(Cc2c[nH]cn2)CC1 Show InChI InChI=1S/C10H17N3/c1-13-4-2-9(3-5-13)6-10-7-11-8-12-10/h7-9H,2-6H2,1H3,(H,11,12)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	<1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vrije Universiteit Amsterdam Curated by ChEMBL					Assay Description Displacement of [125I]aminopotentidine binding to CHO cell membranes expressing human histamine H2 receptor				J Med Chem 48: 2100-7 (2005) Article DOI: 10.1021/jm049475h BindingDB Entry DOI: 10.7270/Q28K7CVC
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50475340 (METHIMEPIP | Methimepip) Show SMILES CN1CCC(Cc2c[nH]cn2)CC1 Show InChI InChI=1S/C10H17N3/c1-13-4-2-9(3-5-13)6-10-7-11-8-12-10/h7-9H,2-6H2,1H3,(H,11,12)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.316	n/a	n/a	n/a	n/a
University of Regensburg Curated by ChEMBL					Assay Description Agonist activity at human histamine H3 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay				Bioorg Med Chem Lett 20: 7191-9 (2010) Article DOI: 10.1016/j.bmcl.2010.10.041 BindingDB Entry DOI: 10.7270/Q2Q81GX5
					More data for this Ligand-Target Pair
Histamine receptor (H3 and H4) (Homo sapiens (Human))	BDBM50475340 (METHIMEPIP | Methimepip) Show SMILES CN1CCC(Cc2c[nH]cn2)CC1 Show InChI InChI=1S/C10H17N3/c1-13-4-2-9(3-5-13)6-10-7-11-8-12-10/h7-9H,2-6H2,1H3,(H,11,12)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	5.01E+3	n/a	n/a	n/a	n/a
University of Regensburg Curated by ChEMBL					Assay Description Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells by CRE-beta galactosidase reporter gene assay				Bioorg Med Chem Lett 20: 7191-9 (2010) Article DOI: 10.1016/j.bmcl.2010.10.041 BindingDB Entry DOI: 10.7270/Q2Q81GX5
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50475340 (METHIMEPIP | Methimepip) Show SMILES CN1CCC(Cc2c[nH]cn2)CC1 Show InChI InChI=1S/C10H17N3/c1-13-4-2-9(3-5-13)6-10-7-11-8-12-10/h7-9H,2-6H2,1H3,(H,11,12)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.316	n/a	n/a	n/a	n/a
Vrije Universiteit Amsterdam Curated by ChEMBL					Assay Description Inhibition of cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing human H3 receptor				J Med Chem 48: 2100-7 (2005) Article DOI: 10.1021/jm049475h BindingDB Entry DOI: 10.7270/Q28K7CVC
					More data for this Ligand-Target Pair