BDBM50492356 CHEMBL2403854

SMILES: Cc1nc2cc(C)ccc2n1[C@@H]1CC[C@@H](CC1)NCC1Cc2ccc(Cl)cc2C1

InChI Key: InChIKey=HNBFYJSHZBDBEP-KWZJIHQYSA-N

Data: 1 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50492356   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Melanin-concentrating hormone receptor (Homo sapiens (Human))	BDBM50492356 (CHEMBL2403854) Show SMILES Cc1nc2cc(C)ccc2n1[C@@H]1CC[C@@H](CC1)NCC1Cc2ccc(Cl)cc2C1 |r,wU:11.12,14.19,(6.58,-24.86,;5.4,-25.85,;3.9,-25.49,;3.09,-26.8,;1.57,-27.07,;1.05,-28.53,;-.46,-28.8,;2.04,-29.7,;3.56,-29.43,;4.09,-27.98,;5.51,-27.4,;6.85,-28.18,;6.79,-29.74,;8.1,-30.55,;9.45,-29.84,;9.51,-28.27,;8.19,-27.45,;10.79,-30.62,;12.13,-29.87,;12.14,-28.33,;10.9,-27.41,;11.39,-25.95,;10.64,-24.62,;11.41,-23.3,;12.95,-23.31,;13.73,-21.99,;13.7,-24.65,;12.92,-25.97,;13.39,-27.43,)| Show InChI InChI=1S/C25H30ClN3/c1-16-3-10-25-24(11-16)28-17(2)29(25)23-8-6-22(7-9-23)27-15-18-12-19-4-5-21(26)14-20(19)13-18/h3-5,10-11,14,18,22-23,27H,6-9,12-13,15H2,1-2H3/t18?,22-,23+	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	20	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. Curated by ChEMBL					Assay Description Antagonist activity at human MCHR1 expressed in CHOK1 cells assessed as inhibition of MCH/forskolin-stimulated cAMP production				Bioorg Med Chem Lett 23: 4216-20 (2013) Article DOI: 10.1016/j.bmcl.2013.05.017 BindingDB Entry DOI: 10.7270/Q2TX3J95
					More data for this Ligand-Target Pair
Melanin-concentrating hormone receptor (Homo sapiens (Human))	BDBM50492356 (CHEMBL2403854) Show SMILES Cc1nc2cc(C)ccc2n1[C@@H]1CC[C@@H](CC1)NCC1Cc2ccc(Cl)cc2C1 |r,wU:11.12,14.19,(6.58,-24.86,;5.4,-25.85,;3.9,-25.49,;3.09,-26.8,;1.57,-27.07,;1.05,-28.53,;-.46,-28.8,;2.04,-29.7,;3.56,-29.43,;4.09,-27.98,;5.51,-27.4,;6.85,-28.18,;6.79,-29.74,;8.1,-30.55,;9.45,-29.84,;9.51,-28.27,;8.19,-27.45,;10.79,-30.62,;12.13,-29.87,;12.14,-28.33,;10.9,-27.41,;11.39,-25.95,;10.64,-24.62,;11.41,-23.3,;12.95,-23.31,;13.73,-21.99,;13.7,-24.65,;12.92,-25.97,;13.39,-27.43,)| Show InChI InChI=1S/C25H30ClN3/c1-16-3-10-25-24(11-16)28-17(2)29(25)23-8-6-22(7-9-23)27-15-18-12-19-4-5-21(26)14-20(19)13-18/h3-5,10-11,14,18,22-23,27H,6-9,12-13,15H2,1-2H3/t18?,22-,23+	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	57	n/a	n/a	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. Curated by ChEMBL					Assay Description Displacement of [125I]MCH peptide from human MCHR1 expressed in CHOK1 cells				Bioorg Med Chem Lett 23: 4216-20 (2013) Article DOI: 10.1016/j.bmcl.2013.05.017 BindingDB Entry DOI: 10.7270/Q2TX3J95
					More data for this Ligand-Target Pair