null

SMILES: NC(Cc1ccc(Cl)c(Cl)c1)(P(O)(O)=O)P(O)(O)=O

InChI Key: InChIKey=RMSYQFMJHXZAPA-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50495689   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Integrase (Human immunodeficiency virus 1)	BDBM50495689 (CHEMBL3116306) Show SMILES NC(Cc1ccc(Cl)c(Cl)c1)(P(O)(O)=O)P(O)(O)=O Show InChI InChI=1S/C8H11Cl2NO6P2/c9-6-2-1-5(3-7(6)10)4-8(11,18(12,13)14)19(15,16)17/h1-3H,4,11H2,(H2,12,13,14)(H2,15,16,17)	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lomonosov Moscow State University Curated by ChEMBL					Assay Description Non-competitive inhibition of HIV-1 integrase expressed in Escherichia coli using [32P]-labeled U5B/U5A DNA as substrate after 1 hr by double-recipro...				Eur J Med Chem 73: 73-82 (2014) Article DOI: 10.1016/j.ejmech.2013.11.028 BindingDB Entry DOI: 10.7270/Q24M97H3
					More data for this Ligand-Target Pair
Integrase (Human immunodeficiency virus 1)	BDBM50495689 (CHEMBL3116306) Show SMILES NC(Cc1ccc(Cl)c(Cl)c1)(P(O)(O)=O)P(O)(O)=O Show InChI InChI=1S/C8H11Cl2NO6P2/c9-6-2-1-5(3-7(6)10)4-8(11,18(12,13)14)19(15,16)17/h1-3H,4,11H2,(H2,12,13,14)(H2,15,16,17)	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lomonosov Moscow State University Curated by ChEMBL					Assay Description Non-competitive inhibition of HIV-1 integrase expressed in Escherichia coli using [32P]-labeled U5B/U5A DNA as substrate after 1 hr by double-recipro...				Eur J Med Chem 73: 73-82 (2014) Article DOI: 10.1016/j.ejmech.2013.11.028 BindingDB Entry DOI: 10.7270/Q24M97H3
					More data for this Ligand-Target Pair
Integrase (Human immunodeficiency virus 1)	BDBM50495689 (CHEMBL3116306) Show SMILES NC(Cc1ccc(Cl)c(Cl)c1)(P(O)(O)=O)P(O)(O)=O Show InChI InChI=1S/C8H11Cl2NO6P2/c9-6-2-1-5(3-7(6)10)4-8(11,18(12,13)14)19(15,16)17/h1-3H,4,11H2,(H2,12,13,14)(H2,15,16,17)	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Lomonosov Moscow State University Curated by ChEMBL					Assay Description Inhibition of HIV-1 integrase expressed in Escherichia coli using [32P]-labeled U5B-2/U5A DNA as substrate assessed as inhibition of strand transfer ...				Eur J Med Chem 73: 73-82 (2014) Article DOI: 10.1016/j.ejmech.2013.11.028 BindingDB Entry DOI: 10.7270/Q24M97H3
					More data for this Ligand-Target Pair
Integrase (Human immunodeficiency virus 1)	BDBM50495689 (CHEMBL3116306) Show SMILES NC(Cc1ccc(Cl)c(Cl)c1)(P(O)(O)=O)P(O)(O)=O Show InChI InChI=1S/C8H11Cl2NO6P2/c9-6-2-1-5(3-7(6)10)4-8(11,18(12,13)14)19(15,16)17/h1-3H,4,11H2,(H2,12,13,14)(H2,15,16,17)	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	7.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Lomonosov Moscow State University Curated by ChEMBL					Assay Description Inhibition of HIV-1 integrase G140S mutant expressed in Escherichia coli using [32P]-labeled U5B/U5A DNA as substrate assessed as inhibition of 3'-pr...				Eur J Med Chem 73: 73-82 (2014) Article DOI: 10.1016/j.ejmech.2013.11.028 BindingDB Entry DOI: 10.7270/Q24M97H3
					More data for this Ligand-Target Pair
Integrase (Human immunodeficiency virus 1)	BDBM50495689 (CHEMBL3116306) Show SMILES NC(Cc1ccc(Cl)c(Cl)c1)(P(O)(O)=O)P(O)(O)=O Show InChI InChI=1S/C8H11Cl2NO6P2/c9-6-2-1-5(3-7(6)10)4-8(11,18(12,13)14)19(15,16)17/h1-3H,4,11H2,(H2,12,13,14)(H2,15,16,17)	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>2.56E+5	n/a	n/a	n/a	n/a	n/a	n/a
Lomonosov Moscow State University Curated by ChEMBL					Assay Description Displacement of [32P]-labeled U5B/U5A DNA from HIV-1 integrase expressed in Escherichia coli in presence of Mg2+				Eur J Med Chem 73: 73-82 (2014) Article DOI: 10.1016/j.ejmech.2013.11.028 BindingDB Entry DOI: 10.7270/Q24M97H3
					More data for this Ligand-Target Pair
Integrase (Human immunodeficiency virus 1)	BDBM50495689 (CHEMBL3116306) Show SMILES NC(Cc1ccc(Cl)c(Cl)c1)(P(O)(O)=O)P(O)(O)=O Show InChI InChI=1S/C8H11Cl2NO6P2/c9-6-2-1-5(3-7(6)10)4-8(11,18(12,13)14)19(15,16)17/h1-3H,4,11H2,(H2,12,13,14)(H2,15,16,17)	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Lomonosov Moscow State University Curated by ChEMBL					Assay Description Inhibition of HIV-1 integrase expressed in Escherichia coli using [32P]-labeled U5B-2/U5A DNA as substrate assessed as inhibition of strand transfer ...				Eur J Med Chem 73: 73-82 (2014) Article DOI: 10.1016/j.ejmech.2013.11.028 BindingDB Entry DOI: 10.7270/Q24M97H3
					More data for this Ligand-Target Pair
Integrase (Human immunodeficiency virus 1)	BDBM50495689 (CHEMBL3116306) Show SMILES NC(Cc1ccc(Cl)c(Cl)c1)(P(O)(O)=O)P(O)(O)=O Show InChI InChI=1S/C8H11Cl2NO6P2/c9-6-2-1-5(3-7(6)10)4-8(11,18(12,13)14)19(15,16)17/h1-3H,4,11H2,(H2,12,13,14)(H2,15,16,17)	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	7.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Lomonosov Moscow State University Curated by ChEMBL					Assay Description Inhibition of HIV-1 integrase N155H mutant expressed in Escherichia coli using [32P]-labeled U5B/U5A DNA as substrate assessed as inhibition of 3'-pr...				Eur J Med Chem 73: 73-82 (2014) Article DOI: 10.1016/j.ejmech.2013.11.028 BindingDB Entry DOI: 10.7270/Q24M97H3
					More data for this Ligand-Target Pair
Integrase (Human immunodeficiency virus 1)	BDBM50495689 (CHEMBL3116306) Show SMILES NC(Cc1ccc(Cl)c(Cl)c1)(P(O)(O)=O)P(O)(O)=O Show InChI InChI=1S/C8H11Cl2NO6P2/c9-6-2-1-5(3-7(6)10)4-8(11,18(12,13)14)19(15,16)17/h1-3H,4,11H2,(H2,12,13,14)(H2,15,16,17)	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Lomonosov Moscow State University Curated by ChEMBL					Assay Description Inhibition of HIV-1 integrase expressed in Escherichia coli using [32P]-labeled U5B/U5A DNA as substrate assessed as inhibition of 3'-processing reac...				Eur J Med Chem 73: 73-82 (2014) Article DOI: 10.1016/j.ejmech.2013.11.028 BindingDB Entry DOI: 10.7270/Q24M97H3
					More data for this Ligand-Target Pair
Integrase (Human immunodeficiency virus 1)	BDBM50495689 (CHEMBL3116306) Show SMILES NC(Cc1ccc(Cl)c(Cl)c1)(P(O)(O)=O)P(O)(O)=O Show InChI InChI=1S/C8H11Cl2NO6P2/c9-6-2-1-5(3-7(6)10)4-8(11,18(12,13)14)19(15,16)17/h1-3H,4,11H2,(H2,12,13,14)(H2,15,16,17)	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>5.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Lomonosov Moscow State University Curated by ChEMBL					Assay Description Displacement of [32P]-labeled U5B/U5A DNA from HIV-1 integrase expressed in Escherichia coli in presence of Mn2+				Eur J Med Chem 73: 73-82 (2014) Article DOI: 10.1016/j.ejmech.2013.11.028 BindingDB Entry DOI: 10.7270/Q24M97H3
					More data for this Ligand-Target Pair
Integrase (Human immunodeficiency virus 1)	BDBM50495689 (CHEMBL3116306) Show SMILES NC(Cc1ccc(Cl)c(Cl)c1)(P(O)(O)=O)P(O)(O)=O Show InChI InChI=1S/C8H11Cl2NO6P2/c9-6-2-1-5(3-7(6)10)4-8(11,18(12,13)14)19(15,16)17/h1-3H,4,11H2,(H2,12,13,14)(H2,15,16,17)	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Lomonosov Moscow State University Curated by ChEMBL					Assay Description Inhibition of HIV-1 GST-tagged integrase-His6-tagged LEDGF complex expressed in Escherichia coli BL21(DE3) using [32P]-labeled U5B/U5A DNA as substra...				Eur J Med Chem 73: 73-82 (2014) Article DOI: 10.1016/j.ejmech.2013.11.028 BindingDB Entry DOI: 10.7270/Q24M97H3
					More data for this Ligand-Target Pair
Integrase (Human immunodeficiency virus 1)	BDBM50495689 (CHEMBL3116306) Show SMILES NC(Cc1ccc(Cl)c(Cl)c1)(P(O)(O)=O)P(O)(O)=O Show InChI InChI=1S/C8H11Cl2NO6P2/c9-6-2-1-5(3-7(6)10)4-8(11,18(12,13)14)19(15,16)17/h1-3H,4,11H2,(H2,12,13,14)(H2,15,16,17)	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	7.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Lomonosov Moscow State University Curated by ChEMBL					Assay Description Inhibition of HIV-1 integrase E92Q mutant expressed in Escherichia coli using [32P]-labeled U5B/U5A DNA as substrate assessed as inhibition of 3'-pro...				Eur J Med Chem 73: 73-82 (2014) Article DOI: 10.1016/j.ejmech.2013.11.028 BindingDB Entry DOI: 10.7270/Q24M97H3
					More data for this Ligand-Target Pair
Integrase (Human immunodeficiency virus 1)	BDBM50495689 (CHEMBL3116306) Show SMILES NC(Cc1ccc(Cl)c(Cl)c1)(P(O)(O)=O)P(O)(O)=O Show InChI InChI=1S/C8H11Cl2NO6P2/c9-6-2-1-5(3-7(6)10)4-8(11,18(12,13)14)19(15,16)17/h1-3H,4,11H2,(H2,12,13,14)(H2,15,16,17)	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	7.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Lomonosov Moscow State University Curated by ChEMBL					Assay Description Inhibition of HIV-1 GST-tagged integrase-His6-tagged LEDGF complex expressed in Escherichia coli BL21(DE3) using [32P]-labeled U5B/U5A DNA as substra...				Eur J Med Chem 73: 73-82 (2014) Article DOI: 10.1016/j.ejmech.2013.11.028 BindingDB Entry DOI: 10.7270/Q24M97H3
					More data for this Ligand-Target Pair
Integrase (Human immunodeficiency virus 1)	BDBM50495689 (CHEMBL3116306) Show SMILES NC(Cc1ccc(Cl)c(Cl)c1)(P(O)(O)=O)P(O)(O)=O Show InChI InChI=1S/C8H11Cl2NO6P2/c9-6-2-1-5(3-7(6)10)4-8(11,18(12,13)14)19(15,16)17/h1-3H,4,11H2,(H2,12,13,14)(H2,15,16,17)	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	7.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Lomonosov Moscow State University Curated by ChEMBL					Assay Description Inhibition of HIV-1 integrase E138K mutant expressed in Escherichia coli using [32P]-labeled U5B/U5A DNA as substrate assessed as inhibition of 3'-pr...				Eur J Med Chem 73: 73-82 (2014) Article DOI: 10.1016/j.ejmech.2013.11.028 BindingDB Entry DOI: 10.7270/Q24M97H3
					More data for this Ligand-Target Pair
Integrase (Human immunodeficiency virus 1)	BDBM50495689 (CHEMBL3116306) Show SMILES NC(Cc1ccc(Cl)c(Cl)c1)(P(O)(O)=O)P(O)(O)=O Show InChI InChI=1S/C8H11Cl2NO6P2/c9-6-2-1-5(3-7(6)10)4-8(11,18(12,13)14)19(15,16)17/h1-3H,4,11H2,(H2,12,13,14)(H2,15,16,17)	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	7.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Lomonosov Moscow State University Curated by ChEMBL					Assay Description Inhibition of HIV-1 integrase expressed in Escherichia coli using [32P]-labeled U5B/U5A DNA as substrate assessed as inhibition of 3'-processing reac...				Eur J Med Chem 73: 73-82 (2014) Article DOI: 10.1016/j.ejmech.2013.11.028 BindingDB Entry DOI: 10.7270/Q24M97H3
					More data for this Ligand-Target Pair